5-(4-氯苯基)-2-呋喃甲酸合成路线 （共 14 条）
反应条件
sodium chlorite; sodium dihydrogenphosphate; 2-methyl-but-2-ene in water; tert-butyl alcohol T=20°C; 11 h;
参考文献
Murasawa, Shinpei; Sato, Shinichi; Noguchi-Yachide, Tomomi; Hashimoto, Yuichi; Iuchi, Katsuya; Sodeoka, Mikiko; Dodo, Kosuke; Yokomatsu, Tsutomu; Aoyama, Hiroshi
Bioorganic and Medicinal Chemistry, 2012 , vol. 20, # 21 p. 6384 - 6393,10
反应条件
1: 4-chloro-aniline With hydrogenchloride; water; sodium nitrite T=0 - 5°C; 2: furan-2-carboxylic acid With ammonium cerium(IV) nitrate in water T=20°C; 7 h;
参考文献
Subrahmanya Bhat; Shivarama Holla
Heterocyclic Communications, 2003 , vol. 9, # 6 p. 625 - 628
反应条件
potassium hydroxide in ethanol 0.5 h; Reflux;
参考文献
Gorak; Obushak; Matiichuk; Lytvyn
Russian Journal of Organic Chemistry, 2009 , vol. 45, # 4 p. 541 - 550
反应条件
1: bis-triphenylphosphine-palladium(II) chloride; sodium carbonate / ethanol; water; ethylene glycol dimethyl ether / 2 h / 60 °C 2: sodium dihydrogenphosphate; 2-methyl-but-2-ene; sodium chlorite / water; tert-butyl alcohol / 11 h / 20 °C View Scheme
参考文献
Murasawa, Shinpei; Sato, Shinichi; Noguchi-Yachide, Tomomi; Hashimoto, Yuichi; Iuchi, Katsuya; Sodeoka, Mikiko; Dodo, Kosuke; Yokomatsu, Tsutomu; Aoyama, Hiroshi
Bioorganic and Medicinal Chemistry, 2012 , vol. 20, # 21 p. 6384 - 6393,10
反应条件
1: bis-triphenylphosphine-palladium(II) chloride; sodium carbonate / ethanol; water; ethylene glycol dimethyl ether / 2 h / 60 °C 2: sodium dihydrogenphosphate; 2-methyl-but-2-ene; sodium chlorite / water; tert-butyl alcohol / 11 h / 20 °C View Scheme
参考文献
Murasawa, Shinpei; Sato, Shinichi; Noguchi-Yachide, Tomomi; Hashimoto, Yuichi; Iuchi, Katsuya; Sodeoka, Mikiko; Dodo, Kosuke; Yokomatsu, Tsutomu; Aoyama, Hiroshi
Bioorganic and Medicinal Chemistry, 2012 , vol. 20, # 21 p. 6384 - 6393,10
反应条件
acetone; copper dichloride
参考文献
Akashi; Oda
Kogyo Kagaku Zasshi, 1952 , vol. 55, p. 271
Chem.Abstr., 1954 , p. 3953
Full Text Show Details
Malinowski
Roczniki Chemii, 1953 , vol. 27, p. 54,59
Chem.Abstr., 1954 , p. 13678
Full Text Show Details
Krutosikova et al.
Collection of Czechoslovak Chemical Communications, 1974 , vol. 39, p. 767,768, 770
反应条件
1-methyl-pyrrolidin-2-one; tetrakis(triphenylphosphine) palladium(0); sodium carbonate Suzuki coupling; Heating;
参考文献
Tumey, L. Nathan; Huck, Bayard; Gleason, Elizabeth; Wang, Jianmin; Silver, Daniel; Brunden, Kurt; Boozer, Sherry; Rundlett, Stephen; Sherf, Bruce; Murphy, Steven; Bailey, Andrew; Dent, Tom; Leventhal, Christina; Harrington, John; Bennani, Youssef L.
Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 19 p. 4915 - 4918
反应条件
1: 53 percent / EDCI; HOBt; DIPEA / dimethylformamide / 0 - 20 °C 2: 68 percent / LAH / tetrahydrofuran / 4 h / -30 °C View Scheme
参考文献
Zhang, Jianmin; Pettersson, Hanna I.; Huitema, Carly; Niu, Chunying; Yin, Jiang; James, Michael N. G.; Eltis, Lindsay D.; Vederas, John C.
Journal of Medicinal Chemistry, 2007 , vol. 50, # 8 p. 1850 - 1864
反应条件
1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 20 °C 2: sodium hydride / N,N-dimethyl-formamide; mineral oil / 20 °C 3: trifluoroacetic acid / 0.25 h / 20 °C View Scheme
参考文献
Huang, Xiaohua; Shipps, Gerald W.; Cheng, Cliff C.; Spacciapoli, Peter; Zhang, Xingmin; McCoy, Mark A.; Wyss, Daniel F.; Yang, Xianshu; Achab, Abdelghani; Soucy, Kyle; Montavon, Donna K.; Murphy, Denise M.; Whitehurst, Charles E.
ACS Medicinal Chemistry Letters, 2011 , vol. 2, # 8 p. 632 - 637
反应条件
1: SOCl2 / DMF / 0.67 h / Heating
2: 91 percent / triethylamine / CHCl3 / 1.) -5 to 0 deg C, 30 min; 2.) r.t., 1 h
3: PCl5 / benzene / 0.25 h / 75 °C
4: sodium azide / dimethylformamide / 0.5 h
5: 1.) 3M KOH, 2.) 15percent HCl / methanol; H2O / 1 h / Heating
View Scheme
参考文献
Janda; Voticky; Svetlik; et al.
Collection of Czechoslovak Chemical Communications, 1984 , vol. 49, # 6 p. 1505 - 1514
