3-(4-氯苯胺基)巴豆酸乙酯合成路线 （共 6 条）
反应条件
1: diphenylether / 0.5 h / |Reflux 2: trichlorophosphate / 3 h / |Reflux 3: hydrazine hydrate / |Reflux View Scheme
参考文献
Luo, Wei; Liu, Yang; Wang, Jian; Guo, Chun; Lu, Wei-Qiang; Cui, Kun-Qiang
Medicinal Chemistry Research, 2012 , vol. 21, # 10 p. 3073 - 3079,7
反应条件
1: diphenylether / 0.5 h / |Reflux 2: trichlorophosphate / 3 h / |Reflux View Scheme
参考文献
Luo, Wei; Liu, Yang; Wang, Jian; Guo, Chun; Lu, Wei-Qiang; Cui, Kun-Qiang
Medicinal Chemistry Research, 2012 , vol. 21, # 10 p. 3073 - 3079,7
反应条件
in diphenylether 0.5 h; Reflux;
参考文献
Luo, Wei; Liu, Yang; Wang, Jian; Guo, Chun; Lu, Wei-Qiang; Cui, Kun-Qiang
Medicinal Chemistry Research, 2012 , vol. 21, # 10 p. 3073 - 3079,7
反应条件
trichlorophosphate in DMF (N,N-dimethyl-formamide); 1,2-dichloro-ethane T=20°C; 7.16667 h; Heating / reflux;
参考文献
Takeuchi, Kumiko; Jirousek, Michael Robert; Paal, Michael; Ruhter, Gerd; Schotten, Theo
Patent: US2004/9976 A1, 2004 ;
Location in patent: Page/Page column 92 ;
反应条件
1: N,N-dimethyl-formamide With trichlorophosphate in 1,2-dichloro-ethane T=20°C; 0.166667 h; 2: ethyl 3-((4-chlorophenyl)amino)but-2-enoate in 1,2-dichloro-ethane T=20°C; Vilsmeier Formylation; 7 h; Heating / reflux;
参考文献
ELI LILLY AND COMPANY
Patent: EP1266897 A2, 2002 ;
Location in patent: Page 110 ;
反应条件
C9H3NO8(2-)*Cu(2+)*2H2O*C7H10N6 in neat (no solvent)
T=20°C; 1 h; chemoselective reaction;
参考文献
Zhao, Ying; Deng, Dong-Sheng; Ma, Lu-Fang; Ji, Bao-Ming; Wang, Li-Ya
Chemical Communications, 2013 , vol. 49, # 87 p. 10299 - 10301
