7-三氟甲基-2H-异喹啉-1-酮合成路线 （共 4 条）
反应条件
in diphenylether; dichloromethane T=260°C;
参考文献
WO2012/35078 A1, ;
Page/Page column 87 ;
WO 2012/035078 A1
反应条件
1.1: piperidine; pyridine / 0.33 h / 20 - 105 °C / Inert atmosphere 1.2: 20 °C / Inert atmosphere 2.1: thionyl chloride / N,N-dimethyl-formamide / dichloromethane / 3 h / 0 - 75 °C / Inert atmosphere 3.1: sodium azide / 1,4-dioxane; water / 0.33 h / 0 °C / Inert atmosphere 4.1: diphenylether; dichloromethane / 260 °C View Scheme
参考文献
WO2012/35078 A1, ;
WO 2012/035078 A1
反应条件
1: thionyl chloride / N,N-dimethyl-formamide / dichloromethane / 3 h / 0 - 75 °C / Inert atmosphere 2: sodium azide / 1,4-dioxane; water / 0.33 h / 0 °C / Inert atmosphere 3: diphenylether; dichloromethane / 260 °C View Scheme
参考文献
WO2012/35078 A1, ;
WO 2012/035078 A1
反应条件
1: sodium azide / 1,4-dioxane; water / 0.33 h / 0 °C / Inert atmosphere 2: diphenylether; dichloromethane / 260 °C View Scheme
参考文献
WO2012/35078 A1, ;
WO 2012/035078 A1
