甲基-2,3-O-异亚丙基-beta-D-呋喃核糖苷合成路线 （共 77 条）
反应条件
1: 56 percent / pyridinium chlorochromate / benzene / Heating
2: 80 percent
View Scheme
参考文献
Ali, Syed Mashhood; Ramesh, Kakarla; Borchardt, Ronald T.
Tetrahedron Letters, 1990 , vol. 31, # 11 p. 1509 - 1512
反应条件
pyridine
T=-10 - -5°C; 4 h; ConcentrationTimeTemperature;
参考文献
LEK Pharmaceuticals d.d.; Sterk, Damjan; Casar Zdenko
Patent: EP2666771 A1, 2013 ;
Location in patent: Paragraph 0049; 0050; 0051; 0055; 0057 ;
反应条件
pyridine
T=0°C; 2 h;
参考文献
Li, Xiang-Guo; Dall'Angelo, Sergio; Schweiger, Lutz F.; Zanda, Matteo; O'Hagan, David
Chemical Communications, 2012 , vol. 48, # 43 p. 5247 - 5249
反应条件
1.1: triphenylphosphine; imidazole; I2 / toluene / Heating
1.2: 85 percent / Zn / methanol / Heating
2.1: 84 percent / tetrahydrofuran / -78 °C
3.1: Grubbs first generation catalyst / CH2Cl2 / 4 h / 20 °C
3.2: 87 percent / PCC / CH2Cl2 / 12 h
4.1: 95 percent / hydrogen / Pd/C / ethyl acetate / 20 °C
View Scheme
参考文献
Smith III, Amos B.; Han, Qiang; Breslin, Paul A. S.; Beauchamp, Gary K.
Organic Letters, 2005 , vol. 7, # 22 p. 5075 - 5078
反应条件
1: 92 percent / pyridine / 5 h / 20 °C
2: 87 percent / Dowex 50H+ / methanol / 48 h / 60 °C
3: 89 percent / DMAP; pyridine / 50 °C
4: 95 percent / AcOH; H2SO4 / 0.5 h / 20 °C
5: 69 percent / stannic chloride / CH2Cl2 / 3 h / Heating
6: 71 percent / triethylamine / methanol / 2 h / 20 °C
7: 74 percent / bromotrichloromethane; 1,8-diazabicyclo[5.4.0]-undec-7-ene / CH2Cl2 / 16 h / 0 °C
View Scheme
参考文献
Kim, Myong Jung; Jeong, Lak Shin; Kim, Joong Hyup; Shin, Ji Hye; Chung, Soon Yong; Lee, Sang Kook; Chun, Moon Woo
Nucleosides, Nucleotides and Nucleic Acids, 2004 , vol. 23, # 4 p. 715 - 724
反应条件
tris-(2-chloro-ethyl)-amine; di-isopropyl azodicarboxylate; triphenylphosphine in tetrahydrofuran
Mitsunobu reaction; 3 h;
参考文献
Ginisty, Maryon; Gravier-Pelletier, Christine; Le Merrer, Yves
Tetrahedron Asymmetry, 2006 , vol. 17, # 1 p. 142 - 150
反应条件
1H-imidazole; iodine; chloro-diphenylphosphine in toluene
0.0833333 h; Ambient temperatureother halogenation reagent systems; Product distribution;
参考文献
Classon, Bjoern; Liu, Zhengchun
Journal of Organic Chemistry, 1988 , vol. 53, # 26 p. 6126 - 6130
