反应条件
1: 1) lithium hexamethyldisilazide / 1) THF, -78 deg C, 1h, 2) room temperature, 30 min 2: tetrahydrofuran / -78 °C 3: DIBAL-H / toluene / 2 h / -78 °C 4: 96 percent / pyridine, DMAP / CH2Cl2 / 2 h / 0 °C 5: 1) hexamethyldisilazane (HMDS), ammonium sulfate, 2) trimethylsilyl triflate (TMSOTf) / 1) reflux, 1 h, 2) 1,2-dichloroethane, a) -22 deg C, 15 min, b) room temperature, 0.5 h 6: 59 percent / ammonia / methanol / 16 h / 80 °C 7: 90.9 percent / n-Bu3SnH, Et3B / benzene; hexane / Ambient temperature 8: 82.4 percent / TBAF / tetrahydrofuran / Ambient temperature View Scheme
参考文献
Beach, J. Warren; Kim, Hea O.; Jeong, Lak S.; Nampalli, Satyanarayana; Islam, Qamrul; et al.
Journal of Organic Chemistry, 1992 , vol. 57, # 14 p. 3887 - 3894
