4-羟基-2-氧代吡咯烷-1-羧酸叔丁酯合成路线 （共 3 条）
反应条件
methanesulfonyl chloride; triethylamine in tetrahydrofuran T=0 - 20°C; 4.5 h; Inert atmosphereLarge scale;
参考文献
Tian, Zhenping; Rasmussen, Michael; Wittenberger, Steven J.
Organic Process Research and Development, 2002 , vol. 6, # 4 p. 416 - 418
反应条件
1: 4-amino-3-(R,S)-hydroxybutyric acid; 1,1,1,3,3,3-hexamethyl-disilazane With pyridine in anhydrous xylene
T=118°C; 14 h; Large scale;
2: di-tert-butyl dicarbonate With 4-(N,N-dimethlyamino)pyridine in isopropanol acetate
T=10 - 20°C; 17.5 h; Large scale;
3: With triethylamine tris(hydrogen fluoride) in isopropanol acetate
1 h; Large scale;
参考文献
Tian, Zhenping; Rasmussen, Michael; Wittenberger, Steven J.
Organic Process Research and Development, 2002 , vol. 6, # 4 p. 416 - 418
反应条件
4-(N,N-dimethlyamino)pyridine; 1,1,1,3,3,3-hexamethyl-disilazane in tetrahydrofuran; pyridine; n-heptane
参考文献
Wittenberger, Steven J.; Bhagavatula, Lakshmi; DeGoey, David A.; DeMattei, John; Gupta, Ashok K.; Hill, David R.; Manna, Sukumar; McLaughlin, Maureen Ann; Nichols, Paul J.; Ramiya, Premchandran H.; Rasmussen, Michael W.; Tian, Zhenping
Patent: US2003/55297 A1, 2003 ;
