4-乙酰胺基-2-甲氧基-5-硝基苯甲酸甲酯合成路线 （共 5 条）
反应条件
nitric acid; acetic anhydride T=-10 - 0°C; 0.166667 h; Inert atmosphere;
参考文献
PETER MACCALLUM CANCER INSTITUTE; MARTIN, Roger, Francis; WHITE, Jonathan; LOBACHEVSKY, Pavel; WINKLER, David; SKENE, Colin; MARCUCCIO, Sebastian
Patent: WO2011/123890 A1, 2011 ;
Location in patent: Page/Page column 119 ;
反应条件
1: ethanol / 2 h / 60 - 65 °C 2: nitric acid; acetic anhydride / 0.17 h / -10 - 0 °C / Inert atmosphere View Scheme
参考文献
PETER MACCALLUM CANCER INSTITUTE; MARTIN, Roger, Francis; WHITE, Jonathan; LOBACHEVSKY, Pavel; WINKLER, David; SKENE, Colin; MARCUCCIO, Sebastian
Patent: WO2011/123890 A1, 2011 ;
反应条件
sulfuric acid in methanol 11 h; RefluxInert atmosphere;
参考文献
Berg, Lotta; Niemiec, Moritz S.; Qian, Weixing; Andersson, C. David; Wittung-Stafshede, Pernilla; Ekstroem, Fredrik; Linusson, Anna
Angewandte Chemie - International Edition, 2012 , vol. 51, # 51 p. 12716 - 12720
Angew. Chem., 2012 , vol. 124, # 51 p. 12888 - 12892,5
反应条件
sodium tetrahydroborate; lt;CoPcgt;(-) in ethanol
T=20°C; 2.5 h;
参考文献
Eckert, Heiner; Kiesel, Yvonne
Angewandte Chemie, 1981 , vol. 93, # 5 p. 477 - 479
反应条件
1: H2 / Pd/C
2: NaNO2, aq. HCl
3: aq. NaOH
View Scheme
参考文献
Hirokawa, Yoshimi; Yamazaki, Hiroshi; Yoshida, Naoyuki; Kato, Shiro
Bioorganic and Medicinal Chemistry Letters, 1998 , vol. 8, # 15 p. 1973 - 1978
