4-乙酰氨基-5-氯-2-甲氧基苯甲酸酯合成路线 （共 16 条）
反应条件
1: With boron trichloride in dichloromethane T=0 - 15°C; 4 h; 2: With water in dichloromethane
参考文献
WO2007/96352 A1, ;
Page/Page column 12; 23-24 ;
WO 2007/096352 A1
参考文献
Institute of Medicinal Molecular Design, Inc.
Patent: EP1352650 A1, 2003 ;
反应条件
hydrogenchloride in ethanol; water
参考文献
Anphar, S.A.
Patent: US4138492 A1, 1979 ;
反应条件
nitric acid T=-35 - -30°C; 0.166667 h;
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 42, # 3 p. 560 - 569
反应条件
1: 91 percent / HNO3 / 0.17 h / 20 °C
2: 94 percent / aq. H2SO4 / methanol / 9 h / Heating
View Scheme
参考文献
InterMune, Inc.
Patent: US2011/152246 A1, 2011 ;
反应条件
1: 91 percent / HNO3 / 0.17 h / 20 °C
2: 94 percent / aq. H2SO4 / methanol / 9 h / Heating
3: H2; Et3N / Pd/C / 6 h / 3800 Torr
View Scheme
参考文献
Renneberg, Dorte; Dervan, Peter B.
Journal of the American Chemical Society, 2003 , vol. 125, # 19 p. 5707 - 5716
