2,3-二氢-吡喃-5-羧酸合成路线 （共 11 条）
反应条件
1: T=0 - 20°C; Inert atmosphere; 2: T=30°C; P=7.50075 Torr; Inert atmosphere; 3: T=120°C; 0.5 h; Inert atmosphere;
参考文献
Schmidt, Bernd; Werner, Frank; Kelling, Alexandra; Schildeb, Uwe
Journal of Heterocyclic Chemistry, 2010 , vol. 47, # 5 p. 1171 - 1175
反应条件
methanol; 1,1-dimethylpropan-1-ol; sodium hydride; anhydrous cobalt diacetate in tetrahydrofuran T=40°C; P=760 Torr; 57 h; Irradiation;
参考文献
Marchal, Joel; Bodiguel, Jacques; Fort, Yves; Caubere, Paul
Journal of Organic Chemistry, 1995 , vol. 60, # 26 p. 8336 - 8340
反应条件
1,1-dimethylpropan-1-ol; sodium hydride; anhydrous cobalt diacetate in tetrahydrofuran T=40°C; P=760 Torr; 57 h; Irradiation;
参考文献
Marchal, Joel; Bodiguel, Jacques; Fort, Yves; Caubere, Paul
Journal of Organic Chemistry, 1995 , vol. 60, # 26 p. 8336 - 8340
反应条件
potassium hydroxide; water in benzene 7 h; Heating;
参考文献
Hojo, Masaru; Masuda, Ryoichi; Sakaguchi, Syuhei; Takagawa, Makoto
Synthesis, 1986 , # 12 p. 1016 - 1017
反应条件
potassium hydroxide; water in benzene 7 h; Heating;
参考文献
Hojo, Masaru; Masuda, Ryoichi; Sakaguchi, Syuhei; Takagawa, Makoto
Synthesis, 1986 , # 12 p. 1016 - 1017
反应条件
potassium hydroxide; water in benzene 6 h; Reflux;
参考文献
Szori, Kornel; Szollosi, Gyoergy; Bartok, Mihaly
New Journal of Chemistry, 2008 , vol. 32, # 8 p. 1354 - 1358
反应条件
phosgene Behandeln des Reaktionsgemisches mit Wasser;
参考文献
Hojo, Masaru; Masuda, Ryoichi; Sakaguchi, Syuhei; Takagawa, Makoto
Synthesis, 1986 , # 12 p. 1016 - 1017
反应条件
lithium aluminium tetrahydride in diethyl ether T=20°C; 1 h; Cooling with ice;
参考文献
Li, Shichang; Shen, Cunzhou; Guo, Wenyuan; Zhang, Xuefei; Liu, Shixin; Liang, Fengyin; Xu, Zhongliang; Pei, Zhong; Song, Huacan; Qiu, Liqin; Lin, Yongcheng; Pang, Jiyan
Marine Drugs, 2013 , vol. 11, # 12 p. 5159 - 5189
反应条件
hydrogen; 30 Pd/C in ethanol T=20°C; 48 h;
参考文献
ENVIVO PHARMACEUTICALS, INC.; RIPKA, Amy; SHAPIRO, Gideon; MCRINER, Andrew, J.; BURSAVICH, Matthew, Gregory
Patent: WO2013/142269 A1, 2013 ;
Location in patent: Paragraph 0563; 0564 ;
反应条件
potassium carbonate in acetone
T=20°C;
参考文献
Li, Shichang; Shen, Cunzhou; Guo, Wenyuan; Zhang, Xuefei; Liu, Shixin; Liang, Fengyin; Xu, Zhongliang; Pei, Zhong; Song, Huacan; Qiu, Liqin; Lin, Yongcheng; Pang, Jiyan
Marine Drugs, 2013 , vol. 11, # 12 p. 5159 - 5189
