N-甲基-4-甲氧基-beta-苯乙胺合成路线 （共 17 条）
反应条件
1: N,N-dimethyl-formamide; thionyl chloride / toluene / 0.5 h / 40 °C / |Inert atmosphere 2: toluene; water / 0.5 h / 0 - 22 °C / |Inert atmosphere 3: borane-THF / tetrahydrofuran / 4 h / |Inert atmosphere; |Reflux View Scheme
参考文献
Nani, Roger R.; Reisman, Sarah E.
Journal of the American Chemical Society, 2013 , vol. 135, # 19 p. 7304 - 7311
反应条件
4-methyl-morpholine; lithium aluminium tetrahydride; N-ethyl-N,N-diisopropylamine; Wang resin 1.) 0 deg C, 2 h; room temp., overnight, 2.) DMF, room temp., overnight, 3.) THF, 60 deg C, 14 h; Yield given. Multistep reaction;
参考文献
Ho, Chih Y.; Kukla, Michael J.
Tetrahedron Letters, 1997 , vol. 38, # 16 p. 2799 - 2802
参考文献
I.G. Farbenind.
Patent: DE501607 , 1928 ;
Fortschr. Teerfarbenfabr. Verw. Industriezweige, vol. 17, p. 2521
反应条件
anschliessend mit Dimethylsulfat und dann mit wss. Aethanol;
参考文献
Lee et al.
Barell-Festschr. <Basel 1946> S. 264,300
参考文献
Kirkwood; Marion
Journal of the American Chemical Society, 1950 , vol. 72, p. 2522
反应条件
hydrogenchloride; chlorine
参考文献
Baltzly; Ardis
Journal of the American Chemical Society, 1944 , vol. 66, p. 311
反应条件
perchloric acid in water
T=90°C; 4 h; Yield given. Yields of byproduct given;
参考文献
Katsu; Ono; Tasaka; Fujita
Chemical and Pharmaceutical Bulletin, 1984 , vol. 32, # 10 p. 4185 - 4188
