3,5-二甲氧基苯胺盐酸盐合成路线 （共 7 条）
反应条件
1.1: diethyl ether / 2 h / 170 °C 2.1: sodium hydroxide; dihydrogen peroxide / tetrahydrofuran; water / 70 °C 2.2: 3 h / 20 °C 2.3: 16 h / 20 °C 3.1: N,N-dimethyl-formamide / 1 h / 70 °C 3.2: 16 h / 70 °C View Scheme
反应条件
1: 100 percent / 0.5 h / 165 °C 2: 50 percent / NaOH; aq. H2O2 / 0.17 h / 100 °C View Scheme
参考文献
Guengoer, Timur; Chen, Ying; Golla, Rajasree; Ma, Zhengping; Corte, James R.; Northrop, John P.; Bin, Bin; Dickson, John K.; Stouch, Terry; Zhou, Rong; Johnson, Susan E.; Seethala, Ramakrishna; Feyen, Jean H. M.
Journal of Medicinal Chemistry, 2006 , vol. 49, # 8 p. 2440 - 2455
参考文献
Zhang, Ai Hua; Jiang, Nan; Gu, Wen; Ma, Jing; Wang, Yu Rong; Song, Yong Chun; Tan, Ren Xiang
Chemistry - A European Journal, 2010 , vol. 16, # 48 p. 14479 - 14485
反应条件
hydrogenchloride in diethyl ether
T=0 - 10°C; 1.5 h;
参考文献
RVX Therapeutics Inc.; McLure, Kevin G.; Young, Peter Ronald
Patent: US2013/281397 A1, 2013 ;
Location in patent: Paragraph 0453 ;
反应条件
1: 100 percent / 0.5 h / 165 °C
2: 50 percent / NaOH; aq. H2O2 / 0.17 h / 100 °C
3: tetrahydrofuran; methanol / 20 °C
View Scheme
参考文献
Guengoer, Timur; Chen, Ying; Golla, Rajasree; Ma, Zhengping; Corte, James R.; Northrop, John P.; Bin, Bin; Dickson, John K.; Stouch, Terry; Zhou, Rong; Johnson, Susan E.; Seethala, Ramakrishna; Feyen, Jean H. M.
Journal of Medicinal Chemistry, 2006 , vol. 49, # 8 p. 2440 - 2455
反应条件
1.1: diethyl ether / 2 h / 170 °C
2.1: sodium hydroxide; dihydrogen peroxide / tetrahydrofuran; water / 70 °C
2.2: 3 h / 20 °C
2.3: 16 h / 20 °C
View Scheme
参考文献
RVX Therapeutics Inc.; McLure, Kevin G.; Young, Peter Ronald
Patent: US2013/281397 A1, 2013 ;
反应条件
1: 100 percent / 0.5 h / 165 °C
2: 50 percent / NaOH; aq. H2O2 / 0.17 h / 100 °C
3: 92 percent / tetrahydrofuran / 0 - 20 °C
View Scheme
参考文献
Guengoer, Timur; Chen, Ying; Golla, Rajasree; Ma, Zhengping; Corte, James R.; Northrop, John P.; Bin, Bin; Dickson, John K.; Stouch, Terry; Zhou, Rong; Johnson, Susan E.; Seethala, Ramakrishna; Feyen, Jean H. M.
Journal of Medicinal Chemistry, 2006 , vol. 49, # 8 p. 2440 - 2455
