2,4-二氯-6-硝基喹啉合成路线 （共 12 条）
反应条件
trichlorophosphate
T=80°C; 2 h;
参考文献
MERCK and CO., INC.
Patent: WO2006/60390 A1, 2006 ;
Location in patent: Page/Page column 32 ;
WO 2006/060390 A1
反应条件
in acetonitrile
T=150°C; 12 h;
参考文献
Lee, Jae Hak; Lee, Byoung Se; Shin, Hyunik; Nam, Do Hyun; Chi, Dae Yoon
Synlett, 2006 , # 1 art. no. U27905ST, p. 65 - 68
反应条件
1: CuI; Et3N / PdCl2(PPh3)2 / tetrahydrofuran / 1 h / 20 °C
2: TBAF / tetrahydrofuran / 0 - 20 °C
3: 55 percent / acetonitrile / 12 h / 150 °C
View Scheme
参考文献
Lee, Jae Hak; Lee, Byoung Se; Shin, Hyunik; Nam, Do Hyun; Chi, Dae Yoon
Synlett, 2006 , # 1 art. no. U27905ST, p. 65 - 68
反应条件
1: aq. K2CO3 / methanol / 24 h / 50 °C
2: CuI; Et3N / PdCl2(PPh3)2 / tetrahydrofuran / 1 h / 20 °C
3: TBAF / tetrahydrofuran / 0 - 20 °C
4: 55 percent / acetonitrile / 12 h / 150 °C
View Scheme
参考文献
Lee, Jae Hak; Lee, Byoung Se; Shin, Hyunik; Nam, Do Hyun; Chi, Dae Yoon
Synlett, 2006 , # 1 art. no. U27905ST, p. 65 - 68
反应条件
trichlorophosphate
T=80°C; 2.5 h;
参考文献
Byung, Seok Moon; Byoung, Se Lee; Dae, Yoon Chi
Bioorganic and Medicinal Chemistry, 2005 , vol. 13, # 16 p. 4952 - 4959
反应条件
1: TBAF / tetrahydrofuran / 0 - 20 °C
2: 55 percent / acetonitrile / 12 h / 150 °C
View Scheme
参考文献
Lee, Jae Hak; Lee, Byoung Se; Shin, Hyunik; Nam, Do Hyun; Chi, Dae Yoon
Synlett, 2006 , # 1 art. no. U27905ST, p. 65 - 68
反应条件
1: polyphosphoric acid / 2.5 h / 120 °C
2: phosphorus oxychloride / 2.5 h / 80 °C
View Scheme
参考文献
Byung, Seok Moon; Byoung, Se Lee; Dae, Yoon Chi
Bioorganic and Medicinal Chemistry, 2005 , vol. 13, # 16 p. 4952 - 4959
反应条件
1: 18 h / 180 °C
2: polyphosphoric acid / 2.5 h / 120 °C
3: phosphorus oxychloride / 2.5 h / 80 °C
View Scheme
参考文献
Byung, Seok Moon; Byoung, Se Lee; Dae, Yoon Chi
Bioorganic and Medicinal Chemistry, 2005 , vol. 13, # 16 p. 4952 - 4959
参考文献
Ishikawa
Proceedings of the Imperial Academy (Tokyo), 1944 , vol. 20, p. 599,603
Chem.Abstr., 1955 , p. 326
参考文献
Ishikawa
Proceedings of the Imperial Academy (Tokyo), 1944 , vol. 20, p. 599,603
Chem.Abstr., 1955 , p. 326
