2-甲氧基-3-硝基-6-氯吡啶合成路线 （共 10 条）
反应条件
sodium hydride in tetrahydrofuran T=0°C; 1 h;
参考文献
Phenex Pharmaceuticals AG
Patent: EP1894924 A1, 2008 ;
Location in patent: Page/Page column 30 ;
反应条件
in tetrahydrofuran T=0 - 20°C; 13.5 h;
参考文献
Eisai Co., Ltd.
Patent: US2006/4013 A1, 2006 ;
Location in patent: Page/Page column 61 ;
US 20060004013 A1
反应条件
in methanol; ethyl acetate
参考文献
Biogen, Inc.
Patent: US6306840 B1, 2001 ;
反应条件
silver carbonate in hexane T=60°C; 1 h; Microwave irradiation;
参考文献
Singh, Brajendra K.; Cavalluzzo, Claudia; De Maeyer, Marc; Debyser, Zeger; Parmar, Virinder S.; Van Der Eycken, Erik
Synthesis, 2009 , # 16 p. 2725 - 2728
反应条件
1.1: NH3 / ethanol 1.2: NaNO2; H2SO4 1.3: H2O 2.1: Ag2CO3 View Scheme
参考文献
Nuss, John M.; Harrison, Stephen D.; Ring, David B.; Boyce, Rustum S.; Johnson, Kirk; Pfister, Keith B.; Ramurthy, Savithri; Seely, Lynn; Wagman, Allan S.; Desai, Manjo; Levine, Barry H.
Patent: US2002/156087 A1, 2002 ;
US 20020156087 A1
反应条件
silver carbonate in toluene 336 h; Ambient temperature;
参考文献
Pomel; Rovera; Godard; Marsais; Queguiner
Journal of Heterocyclic Chemistry, 1996 , vol. 33, # 6 p. 1995 - 2005
参考文献
Ernst, Justin T.; Becerril, Jorge; Park, Hyung Soon; Yin, Hang; Hamilton, Andrew D.
Angewandte Chemie - International Edition, 2003 , vol. 42, # 5 p. 535 - 539
反应条件
1: methanol With sodium hydride in toluene Inert atmosphere; 2: 2,6-dichloro-3-nitro-pyridine in toluene T=0 - 20°C; 16.5 h; Inert atmosphere; regioselective reaction;
参考文献
Yap, Jeremy L.; Hom, Kellie; Fletcher, Steven
Tetrahedron Letters, 2011 , vol. 52, # 32 p. 4172 - 4176
反应条件
1: 80 percent / NaNO2, conc. H2SO4 / 0.5 h / 0 °C 2: 40 percent / Ag2CO3 / toluene / 336 h / Ambient temperature View Scheme
参考文献
Pomel; Rovera; Godard; Marsais; Queguiner
Journal of Heterocyclic Chemistry, 1996 , vol. 33, # 6 p. 1995 - 2005
反应条件
1.1: [Pd(PPh3)4]
2.1: O3 / acetic acid
2.2: AgNO3; KOH
3.1: PTSA
4.1: H2 / Pd/C
View Scheme
参考文献
Ernst, Justin T.; Becerril, Jorge; Park, Hyung Soon; Yin, Hang; Hamilton, Andrew D.
Angewandte Chemie - International Edition, 2003 , vol. 42, # 5 p. 535 - 539
