2-(Boc-氨甲基)苯乙酸合成路线 （共 7 条）
反应条件
lithium hydroxide in tetrahydrofuran; water T=20°C;
参考文献
Le Bourdonnec, Bertrand; Ajello, Christopher William; Dolle, Roland E.
Patent: US2004/254156 A1, 2004 ;
Location in patent: Page 16 ;
反应条件
1: H2SO4 / Heating 2: dimethylformamide / Heating 3: H2; aq. HCl / Pd/C / methanol / 25 °C / 3620.04 Torr 4: Et3N / tetrahydrofuran / 25 °C 5: aq. LiOH / tetrahydrofuran / 25 °C View Scheme
参考文献
Le Bourdonnec, Bertrand; Ajello, Christopher W.; Seida, Pamela R.; Susnow, Roberta G.; Cassel, Joel A.; Belanger, Serge; Stabley, Gabriel J.; DeHaven, Robert N.; DeHaven-Hudkins, Diane L.; Dolle, Roland E.
Bioorganic and Medicinal Chemistry Letters, 2005 , vol. 15, # 10 p. 2647 - 2652
反应条件
1: dimethylformamide / Heating 2: H2; aq. HCl / Pd/C / methanol / 25 °C / 3620.04 Torr 3: Et3N / tetrahydrofuran / 25 °C 4: aq. LiOH / tetrahydrofuran / 25 °C View Scheme
参考文献
Le Bourdonnec, Bertrand; Ajello, Christopher W.; Seida, Pamela R.; Susnow, Roberta G.; Cassel, Joel A.; Belanger, Serge; Stabley, Gabriel J.; DeHaven, Robert N.; DeHaven-Hudkins, Diane L.; Dolle, Roland E.
Bioorganic and Medicinal Chemistry Letters, 2005 , vol. 15, # 10 p. 2647 - 2652
反应条件
1: H2; aq. HCl / Pd/C / methanol / 25 °C / 3620.04 Torr 2: Et3N / tetrahydrofuran / 25 °C 3: aq. LiOH / tetrahydrofuran / 25 °C View Scheme
参考文献
Le Bourdonnec, Bertrand; Ajello, Christopher W.; Seida, Pamela R.; Susnow, Roberta G.; Cassel, Joel A.; Belanger, Serge; Stabley, Gabriel J.; DeHaven, Robert N.; DeHaven-Hudkins, Diane L.; Dolle, Roland E.
Bioorganic and Medicinal Chemistry Letters, 2005 , vol. 15, # 10 p. 2647 - 2652
反应条件
1: Et3N / tetrahydrofuran / 25 °C 2: aq. LiOH / tetrahydrofuran / 25 °C View Scheme
参考文献
Le Bourdonnec, Bertrand; Ajello, Christopher W.; Seida, Pamela R.; Susnow, Roberta G.; Cassel, Joel A.; Belanger, Serge; Stabley, Gabriel J.; DeHaven, Robert N.; DeHaven-Hudkins, Diane L.; Dolle, Roland E.
Bioorganic and Medicinal Chemistry Letters, 2005 , vol. 15, # 10 p. 2647 - 2652
反应条件
sec.-butyllithium 1.) THF, cyclohexane, -35 deg C, 2.) THF, cyclohexane; Yield given. Multistep reaction;
参考文献
Clark, Robin D.; Jahangir
Heterocycles, 1991 , vol. 32, # 9 p. 1699 - 1703
反应条件
hydrogenchloride in ethanol
参考文献
Clark, Robin D.; Jahangir
Heterocycles, 1991 , vol. 32, # 9 p. 1699 - 1703
