1: methylthioacetic acid ethyl ester With sulfuryl dichloride in dichloromethane
T=-78°C; 1.3 h;
2: aniline With 2,6-dimethylpyridine in dichloromethane
T=-78°C; 1 h;
3: With triethylamine in dichloromethane
T=-78 - 20°C;
参考文献
Huang, Audris; Kodanko, Jeremy J.; Overman, Larry E.
Journal of the American Chemical Society, 2004 , vol. 126, # 43 p. 14043 - 14053
1: 5-Aminobenzotriazole With Sodium hydride in DMF (N,N-dimethyl-formamide)
T=20°C; 0.333333 h; Under N2;
2: di-tert-butyl dicarbonate in DMF (N,N-dimethyl-formamide)
2 h;
参考文献
Harris, Philip Anthony; McNutt JR., Robert Walton; Kuyper, Lee Frederick; Lackey, Karen Elizabeth; Peel, Michael Robert; Wood III, Edgar Raymond
Patent: US2003/225090 A1, 2003 ;
Location in patent: Page 24 ;
US 20030225090 A1
