3,5-双-o-(t-丁基二甲基甲硅烷基)胸腺嘧啶脱氧核苷合成路线 （共 38 条）
反应条件
n-butyllithium; methyl iodide in tetrahydrofuran; hexane
T=-78°C;
参考文献
Alauddin, Mian M.; Conti, Peter S.
Tetrahedron, 1994 , vol. 50, # 6 p. 1699 - 1706
反应条件
n-butyllithium in tetrahydrofuran; hexane
T=-78°C;
参考文献
Alauddin, Mian M.; Conti, Peter S.
Tetrahedron, 1994 , vol. 50, # 6 p. 1699 - 1706
反应条件
in N-methyl-acetamide
参考文献
University of Washington
Patent: US6132776 A1, 2000 ;
反应条件
1H-imidazole in N,N-dimethyl-formamide
2.5 h; Ambient temperature;
参考文献
Buchko; Hruska; Sadana
Canadian Journal of Chemistry, 1989 , vol. 67, # 1 p. 109 - 119
反应条件
N,N,N',N,-tetramethylethylenediamine; sec.-butyllithium in tetrahydrofuran
T=-78°C; Yield given. Yields of byproduct given;
参考文献
Armstrong, Robert W.; Gupta, Saaket; Whelihan, Fayelle
Tetrahedron Letters, 1989 , vol. 30, # 16 p. 2057 - 2060
反应条件
butane-1-thiol in acetonitrile
UV-irradiation;
参考文献
Manette, Antonio; Georganakis, Dimitris; Leondiadis, Leondios; Gimisis, Thanasis; Mayer, Peter; Carell, Thomas; Chatgilialoglu, Chryssostomos
Journal of Organic Chemistry, 2007 , vol. 72, # 10 p. 3659 - 3666
反应条件
1: 43 percent / tetrahydrofuran / 0.03 h / -78 °C
2: 88 percent / aq. HCl / tetrahydrofuran / 3 h / 20 °C
3: 1-butanethiol / acetonitrile / UV-irradiation
View Scheme
参考文献
Manette, Antonio; Georganakis, Dimitris; Leondiadis, Leondios; Gimisis, Thanasis; Mayer, Peter; Carell, Thomas; Chatgilialoglu, Chryssostomos
Journal of Organic Chemistry, 2007 , vol. 72, # 10 p. 3659 - 3666
反应条件
1: 88 percent / aq. HCl / tetrahydrofuran / 3 h / 20 °C
2: 1-butanethiol / acetonitrile / UV-irradiation
View Scheme
参考文献
Manette, Antonio; Georganakis, Dimitris; Leondiadis, Leondios; Gimisis, Thanasis; Mayer, Peter; Carell, Thomas; Chatgilialoglu, Chryssostomos
Journal of Organic Chemistry, 2007 , vol. 72, # 10 p. 3659 - 3666
反应条件
1: 45 percent / LiOEt / tetrahydrofuran / 20 °C
2: 43 percent / tetrahydrofuran / 0.03 h / -78 °C
3: 88 percent / aq. HCl / tetrahydrofuran / 3 h / 20 °C
4: 1-butanethiol / acetonitrile / UV-irradiation
View Scheme
参考文献
Manette, Antonio; Georganakis, Dimitris; Leondiadis, Leondios; Gimisis, Thanasis; Mayer, Peter; Carell, Thomas; Chatgilialoglu, Chryssostomos
Journal of Organic Chemistry, 2007 , vol. 72, # 10 p. 3659 - 3666
反应条件
1: 65 percent / TEA / tetrahydrofuran / 40 h / 75 °C
2: 52 percent / n-BuLi, MeI / tetrahydrofuran; hexane / -78 °C
View Scheme
参考文献
Alauddin, Mian M.; Conti, Peter S.
Tetrahedron, 1994 , vol. 50, # 6 p. 1699 - 1706
