4-苄氧基-2-溴-5-甲氧基-苯甲醛合成路线 （共 18 条）
反应条件
1: 88 percent / KOH / tetrahydrofuran; H2O / 2 h / Ambient temperature
2: 98 percent / dimethylformamide / 3 h / 80 °C
View Scheme
参考文献
Martin
Helvetica Chimica Acta, 1989 , vol. 72, # 7 p. 1554 - 1582
反应条件
hydrogen bromide; sodium nitrite; copper(I) bromide
Yield given;
参考文献
Kobayashi, Shigeru; Okimoto, Kazuto; Imakura, Yasuhiro
Chemical & Pharmaceutical Bulletin, 1982 , vol. 30, # 5 p. 1567 - 1573
反应条件
1: 80 percent / N,N-diisopropylethylamine / dimethylformamide / 30 °C
2: 69 percent / sodium acetate; bromine / acetic acid / 11 h / 40 °C
View Scheme
参考文献
Fukuyama, Yoshiyasu; Yaso, Hideyuki; Mori, Takashi; Takahashi, Hironobu; Minami, Hiroyuki; Kodama, Mitsuaki
Heterocycles, 2001 , vol. 54, # 1 p. 259 - 274
反应条件
1: 80 percent / N,N-diisopropylethylamine / dimethylformamide / 30 °C
2: 69 percent / sodium acetate; bromine / acetic acid / 11 h / 40 °C
View Scheme
参考文献
Fukuyama, Yoshiyasu; Yaso, Hideyuki; Mori, Takashi; Takahashi, Hironobu; Minami, Hiroyuki; Kodama, Mitsuaki
Heterocycles, 2001 , vol. 54, # 1 p. 259 - 274
反应条件
1: FeSO4*7H2O, 25 percent NH4OH / 0.08 h / 100 °C
2: 20 percent HBr; NaNO2; 47 percent HBr / CuBr
View Scheme
参考文献
Kobayashi, Shigeru; Okimoto, Kazuto; Imakura, Yasuhiro
Chemical & Pharmaceutical Bulletin, 1982 , vol. 30, # 5 p. 1567 - 1573
反应条件
1: 25 percent / phenylmethanol; dimethylsulfoxide / 0.15 h / 150 °C
2: 77 percent / 2 percent NaOH / 1 h / 85 °C
View Scheme
参考文献
Kobayashi, Shigeru; Okimoto, Kazuto; Imakura, Yasuhiro
Chemical & Pharmaceutical Bulletin, 1982 , vol. 30, # 5 p. 1567 - 1573
反应条件
1: 12 mg / 2 percent NaOH / 1 h / 85 °C
2: FeSO4*7H2O, 25 percent NH4OH / 0.08 h / 100 °C
3: 20 percent HBr; NaNO2; 47 percent HBr / CuBr
View Scheme
参考文献
Kobayashi, Shigeru; Okimoto, Kazuto; Imakura, Yasuhiro
Chemical & Pharmaceutical Bulletin, 1982 , vol. 30, # 5 p. 1567 - 1573
反应条件
sodium tetrahydroborate in methanol
T=20°C; 1 h; Inert atmosphere;
参考文献
Gopi Krishna Reddy; Krishna; Satyanarayana
Tetrahedron Letters, 2012 , vol. 53, # 42 p. 5635 - 5640
