6-(N-三氟乙酰基)氨基己酸合成路线 （共 10 条）
反应条件
dicyclohexyl-carbodiimide in dichloromethane
参考文献
Wako Pure Chemical Industries, Ltd.
Patent: EP2006289 A1, 2008 ;
Location in patent: Page/Page column 41; 98; 112 ;
反应条件
pyridine in acetonitrile T=20°C; 13 h;
参考文献
Johns Hopkins University School of Medicine
Patent: EP1235851 B1, 2006 ;
Location in patent: Page/Page column 53 ;
反应条件
dicyclohexyl-carbodiimide 12 h; Inert atmosphere;
参考文献
Jagt, Richard B. C.; Gomez-Biagi, Rodolfo F.; Nitz, Mark
Angewandte Chemie - International Edition, 2009 , vol. 48, # 11 p. 1995 - 1997
反应条件
trifluoroacetic anhydride in water
参考文献
TAMIR BIOTECHNOLOGY LTD.
Patent: EP267996 A1, 1988 ;
反应条件
triethylamine in methanol
8 h;
参考文献
Johns Hopkins University School of Medicine
Patent: EP1235851 B1, 2006 ;
Location in patent: Page/Page column 53 ;
反应条件
triethylamine in methanol
T=20°C; 18 h;
参考文献
McKeen, Catherine M.; Brown, Lynda J.; Nicol, Jamie T.G.; Mellor, John M.; Brown, Tom
Organic and Biomolecular Chemistry, 2003 , vol. 1, # 13 p. 2267 - 2275
反应条件
water
T=20°C; 1 h; Cooling with ice;
参考文献
Kleschyov, Andrei L.; Sen', Vasily; Golubev, Valery; Muennemann, Kerstin; Hinderberger, Dariush; Lackner, Karl J.; Weber, Stefan; Terekhov, Maxim; Schreiber, Laura M.; Muenzel, Thomas
European Journal of Medicinal Chemistry, 2012 , vol. 58, p. 265 - 271
反应条件
in N,N-dimethyl-formamide
参考文献
De Vos; Van Elsen; Bollen
Nucleosides and Nucleotides, 1994 , vol. 13, # 10 p. 2245 - 2265
反应条件
T=20 - 80°C; 4 h; Inert atmosphere;
参考文献
Robins, Morris J.; Peng, Yunshan; Damaraju, Vijaya L.; Mowles, Delores; Barron, Geraldine; Tackaberry, Tracey; Young, James D.; Cass, Carol E.
Journal of Medicinal Chemistry, 2010 , vol. 53, # 16 p. 6040 - 6053
反应条件
N'-(3-dimethylaminopropyl)-N-ethylcarbodiimide in N,N-dimethyl-formamide
T=20°C; 18 h;
参考文献
McKeen, Catherine M.; Brown, Lynda J.; Nicol, Jamie T.G.; Mellor, John M.; Brown, Tom
Organic and Biomolecular Chemistry, 2003 , vol. 1, # 13 p. 2267 - 2275
