1-溴-4-三氟甲氧基苯合成路线 （共 46 条）
反应条件
bromine; iron T=100°C; 16 h;
参考文献
JIANGSU HENGRUI MEDICINE CO., LTD.; SHANGHAI HENGRUI PHARMACEUTICAL CO., LTD.; Yang, Fanglong; Tang, Peng Cho; Dong, Qing; Tu, Wangyang; Fan, Jiang; Guan, Dongliang; Shen, Guangyuan; Wang, Yang; Yuan, Jijun; Zhang, Limin
Patent: US2013/130997 A1, 2013 ;
Location in patent: Paragraph 0150 ;
反应条件
1,3-dibromo-5,5-dimethyl-hydantoin; pyridine-nonakis(hydrogen fluoride) in dichloromethane T=0°C; 1 h;
参考文献
Kanie, Kiyoshi; Tanaka, Yoichiro; Suzuki, Kazundo; Kuroboshi, Manabu; Hiyama, Tamejiro
Bulletin of the Chemical Society of Japan, 2000 , vol. 73, # 2 p. 471 - 484
反应条件
1: With trifluoromethanesulfonic acid trifluoromethyl ester; sodium hydrogencarbonate in tetrahydrofuran T=-30°C; Inert atmosphere; 2: With AgPF6; F-TEDA-PF6 in tetrahydrofuran; acetone T=-30 - 23°C; Inert atmosphereDarkness;
参考文献
Huang, Chenghong; Liang, Theresa; Harada, Shinji; Lee, Eunsung; Ritter, Tobias
Journal of the American Chemical Society, 2011 , vol. 133, # 34 p. 13308 - 13310
反应条件
1: 5-tert-butyl-2'-(trifluoromethoxy)biphenylyl-2-diazonium hexafluoroantimonate in dichloromethane T=-100 - -90°C; 1.16667 h; Irradiation; 2: 4-bromo-phenol With N-ethyl-N,N-diisopropylamine in dichloromethane T=-90 - -10°C; 3 h; Further stages.;
参考文献
Umemoto, Teruo; Adachi, Kenji; Ishihara, Sumi
Journal of Organic Chemistry, 2007 , vol. 72, # 18 p. 6905 - 6917
参考文献
Imperial Chemical Industries PLC
Patent: US4891450 A1, 1990 ;
反应条件
bromine; iron(III) chloride in nitromethane T=25°C; 1 h; investigation of the bromination reaction; relative reactivity data compared to benzene; Product distribution;
参考文献
Olah,G.A.; Yamato,T.; Hashimoto,T.
Journal of the American Chemical Society, 1987 , vol. 109, p. 3708
反应条件
1.1: sodium hydride / dimethylformamide / 10 h / 20 °C 1.2: 67 percent / dimethylformamide / 1 h / 20 °C 2.1: 62 percent / 70 percent HF/pyridine; 1,3-dibromo-5,5-dimethylhydantoin / CH2Cl2 / 1 h / -78 - 0 °C View Scheme
参考文献
Kanie, Kiyoshi; Tanaka, Yoichiro; Suzuki, Kazundo; Kuroboshi, Manabu; Hiyama, Tamejiro
Bulletin of the Chemical Society of Japan, 2000 , vol. 73, # 2 p. 471 - 484
反应条件
sulfur(IV) fluoride 1.) a) 100 deg C, 1 h, b) 140 deg C, 2 h, 2.) 140 deg C, 4 h; Yield given. Multistep reaction;
参考文献
Pavia, Michael R.; Lobbestael, Sandra J.; Nugiel, David; Mayhugh, Daniel R.; Gregor, Vlad E.; et al.
Journal of Medicinal Chemistry, 1992 , vol. 35, # 22 p. 4238 - 4248
反应条件
1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate / dimethyl sulfoxide / 2 h / 80 °C / |Inert atmosphere 2: dimethyl sulfoxide / 0.5 h / 20 °C View Scheme
参考文献
Tetrahedron Letters, , vol. 54, # 2 p. 166 - 169
反应条件
1: With isopropylmagnesium chloride lithium chloride complex in tetrahydrofuran T=0°C; 2: With methanol in tetrahydrofuran Reactivity;
参考文献
Shi, Lei; Chu, Yuanyuan; Knoechel, Paul; Mayr, Herbert
Journal of Organic Chemistry, 2009 , vol. 74, # 7 p. 2760 - 2764
