5-氯-2-羟基苯甲酸甲酯合成路线 （共 50 条）
反应条件
1: concentrated sulfuric acid / bei der Destillation 2: chlorine View Scheme
参考文献
Cahours
Annales de Chimie (Cachan, France), 1844 , vol. <3> 10, p. 329,336, 353
Justus Liebigs Annalen der Chemie, 1843 , vol. 48, p. 65
参考文献
Bougault; Chabrier
Comptes Rendus Hebdomadaires des Seances de l'Academie des Sciences, 1941 , vol. 213, p. 400
参考文献
Cahours
Annales de Chimie (Cachan, France), 1844 , vol. <3> 10, p. 329,336, 353
Justus Liebigs Annalen der Chemie, 1843 , vol. 48, p. 65
参考文献
Lassar-Cohn; Schultze
Chemische Berichte, 1905 , vol. 38, p. 3294,3301
参考文献
Piutti; Badolato
Atti della Accademia Nazionale dei Lincei, Classe di Scienze Fisiche, Matematiche e Naturali, Rendiconti, 1924 , vol. <5> 33 I, p. 478
参考文献
Chabrier
Annales de Chimie (Cachan, France), 1942 , vol. <11>17, p. 357
Full Text Show Details
Bougault; Chabrier
Comptes Rendus Hebdomadaires des Seances de l'Academie des Sciences, 1941 , vol. 213, p. 312,313
参考文献
Piutti; Badolato
Atti della Accademia Nazionale dei Lincei, Classe di Scienze Fisiche, Matematiche e Naturali, Rendiconti, 1924 , vol. <5> 33 I, p. 478
反应条件
1: potassium carbonate / acetone / Reflux 2: potassium tert-butylate / tetrahydrofuran / 2 h / 0 °C View Scheme
参考文献
PFIZER INC.; AM ENDE, Christopher William; JOHNSON, Douglas Scott; O'DONNELL, Christopher John; PETTERSSON, Martin Youngjin; SUBRAMANYAM, Chakrapani
Patent: WO2011/48525 A1, 2011 ;
WO 2011/048525 A1
反应条件
1: 10percent aq. NaOH / toluene 2: 98 percent / 0.3 molpercent Pd0 / toluene View Scheme
参考文献
Frantz, Doug E.; Weaver, Damian G.; Carey, James P.; Kress, Michael H.; Dolling, Ulf H.
Organic Letters, 2002 , vol. 4, # 26 p. 4717 - 4718
反应条件
1: 86 percent / HNO3, conc. H2SO4 / 1 h / 0 - 5 °C 2: 79 percent / 0.78N aq. NH4Cl, Fe / toluene / 1 h / 85 - 90 °C 3: aq. NaHCO3 / CHCl3 / 2 h / 0 - 10 °C 4: K2CO3 / dimethylformamide / 2 h / 70 °C 5: 82.2 percent / K2CO3 / dimethylformamide / a) RT, 3 h, b) 40-45 deg C, 1 h 6: 81.5 percent / 5percent NaOH / ethanol / 3 h / Heating 7: 97.5 percent / NaOH, H2 / Pd/C / H2O; ethanol / 5.5 h View Scheme
参考文献
Kawakita; Kuroita; Yasumoto; Sano; Inaba; Fukuda; Tahara
Chemical and Pharmaceutical Bulletin, 1992 , vol. 40, # 3 p. 624 - 630
