5-氯-2-羟基苯甲酸甲酯合成路线

参考文献

Erbamont Inc.
Patent: EP234872 B1, 1991 ;

67-56-1甲醇+321-14-25-氯代水杨酸→4068-78-45-氯-2-羟基苯甲酸甲酯

参考文献

PFIZER INC.; AM ENDE, Christopher William; JOHNSON, Douglas Scott; O'DONNELL, Christopher John; PETTERSSON, Martin Youngjin; SUBRAMANYAM, Chakrapani
Patent: WO2011/48525 A1, 2011 ;
Location in patent: Page/Page column 47 ;
WO 2011/048525 A1

→4068-78-45-氯-2-羟基苯甲酸甲酯

参考文献

Erbamont, Inc.
Patent: US4888353 A1, 1989 ;
US 4888353 A

119-36-8柳酸甲酯→4068-78-45-氯-2-羟基苯甲酸甲酯

参考文献

Bovonsombat, Pakorn; Ali, Rameez; Khan, Chiraphorn; Leykajarakul, Juthamard; Pla-On, Kawin; Aphimanchindakul, Suraj; Pungcharoenpong, Natchapon; Timsuea, Nisit; Arunrat, Anchalee; Punpongjareorn, Napat
Tetrahedron, 2010 , vol. 66, # 34 p. 6928 - 6935

321-14-25-氯代水杨酸+75-36-5乙酰氯→4068-78-45-氯-2-羟基苯甲酸甲酯

参考文献

ARROW THERAPEUTICS LIMITED; ASTRAZENECA UK LIMITED; BARNES, Michael, Christopher, Stratton; FLACK, Stephen, Sean; FRASER, Ian; LUMLEY, James, Andrew; PANG, Pui Shan; SPENCER, Keith, Charles; TIBERGHIEN, Nathalie, Anne, Laure; TOMKINSON, Gary, Peter
Patent: WO2011/151651 A1, 2011 ;
Location in patent: Page/Page column 58 ;
WO 2011/151651 A1

321-14-25-氯代水杨酸+74-88-4甲基碘→4068-78-45-氯-2-羟基苯甲酸甲酯

参考文献

Li, Yan; Ding, Yan-Jun; Wang, Jian-Yong; Su, Yi-Ming; Wang, Xi-Sheng
Organic Letters, 2013 , vol. 15, # 11 p. 2574 - 2577

67-56-1甲醇→813-78-5磷酸二甲酯+4068-78-45-氯-2-羟基苯甲酸甲酯

参考文献

Edwards, David R.; Neverov, Alexei A.; Brown, R. Stan
Journal of the American Chemical Society, 2009 , vol. 131, p. 368 - 377

→512-56-1磷酸三甲酯+4068-78-45-氯-2-羟基苯甲酸甲酯

参考文献

Edwards, David R.; Liu, C. Tony; Garrett, Graham E.; Neverov, Alexei A.; Brown, R. Stan
Journal of the American Chemical Society, 2009 , vol. 131, # 38 p. 13738 - 13748

1126-46-1对氯苯甲酸甲酯→4068-78-45-氯-2-羟基苯甲酸甲酯+22717-55-14-氯-2-羟基苯甲酸甲酯+873-76-74-氯苯甲醇

参考文献

Boyd, Derek R.; Sharma, Narain D.; Harrison, John S.; Malone, John. F.; McRoberts, W. Colin; Hamilton, John T. G.; Harper, David B.
Organic and Biomolecular Chemistry, 2008 , vol. 6, # 7 p. 1251 - 1259

117369-90-1→4068-78-45-氯-2-羟基苯甲酸甲酯+117370-02-2

参考文献

Snider,B.B.; Patricia,J.J.
Journal of Organic Chemistry, 1989 , vol. 54, p. 38