N-(4-叔丁基-2-硝基苯基)乙酰胺合成路线 （共 12 条）
反应条件
potassium hydroxide in ethanol 0.25 h; Inert atmosphereReflux;
参考文献
Frantz, Derik K.; Linden, Anthony; Baldridge, Kim K.; Siegel, Jay S.
Journal of the American Chemical Society, 2012 , vol. 134, # 3 p. 1528 - 1535
反应条件
1: 9 M HCl / 0.5 h / Heating 2: H2 / Pd/C / ethanol View Scheme
参考文献
Kuhler; Fryklund; Bergman; Weilitz; Lee; Larsson
Journal of Medicinal Chemistry, 1995 , vol. 38, # 25 p. 4906 - 4916
反应条件
1: potassium hydroxide / ethanol / 0.25 h / Inert atmosphere; Reflux 2: bromine; acetic acid / 0.5 h / 20 °C / Air View Scheme
参考文献
Journal of the American Chemical Society, , vol. 134, # 3 p. 1528 - 1535
反应条件
1: NaOMe 2: (i) NaNO2, H2SO4, (ii) (heating) View Scheme
参考文献
Chapman,N.B. et al.
Journal of Organic Chemistry, 1970 , vol. 35, p. 917 - 923
反应条件
nitric acid; acetic anhydride; acetic acid
T=5°C; 0.25 h;
参考文献
Reuter, Raphael; Hostettler, Nik; Neuburger, Markus; Wegner, Hermann A.
European Journal of Organic Chemistry, 2009 , # 32 p. 5647 - 5652
反应条件
nitric acid in water
T=10 - 20°C; Cooling with ice bath;
参考文献
CONCERT PHARMACEUTICALS, INC.; LIU, Julie, F.; HARBESON, Scott, L.
Patent: WO2011/47315 A1, 2011 ;
Location in patent: Page/Page column 51 ;
WO 2011/047315 A1
反应条件
1: 72 percent / conc. H2SO4, conc. HNO3 / 1 h
2: H2 / Pd/C / ethanol
3: 2 h / 110 °C
4: fuming nitric acid / 0 - 5 °C
View Scheme
参考文献
Kuhler; Fryklund; Bergman; Weilitz; Lee; Larsson
Journal of Medicinal Chemistry, 1995 , vol. 38, # 25 p. 4906 - 4916
反应条件
1: H2 / Pd/C / ethanol
2: 2 h / 110 °C
3: fuming nitric acid / 0 - 5 °C
View Scheme
参考文献
Kuhler; Fryklund; Bergman; Weilitz; Lee; Larsson
Journal of Medicinal Chemistry, 1995 , vol. 38, # 25 p. 4906 - 4916
参考文献
Wilshire, John F. K.
Australian Journal of Chemistry, 1982 , vol. 35, # 12 p. 2497 - 2504
反应条件
1: 2 h / 110 °C
2: fuming nitric acid / 0 - 5 °C
View Scheme
参考文献
Kuhler; Fryklund; Bergman; Weilitz; Lee; Larsson
Journal of Medicinal Chemistry, 1995 , vol. 38, # 25 p. 4906 - 4916
