3-甲基-5-硝基-1H-吲唑合成路线 (共 9 条)
反应条件
hydrazine in ethylene glycol T=20 - 165°C; 26 h;
参考文献
Nagarathnam, Dhanapalan; Khire, Uday; Asgari, Davoud; Shao, Jianxing; Liu, Xiao-Gao; Wang, Chunguang; Hart, Barry; Weber, Olaf; Lynch, Mark; Zhang, Lei; Wang, Lei
Patent: US2004/14755 A1, 2004 ;
Location in patent: Page/Page column 21 ;
US 20040014755 A1
反应条件
hydrazine T=150°C; 0.0833333 h; Microwave irradiation;
参考文献
DAEWOONG PHARMACEUTICAL CO., LTD.
Patent: WO2006/109933 A1, 2006 ;
Location in patent: Page/Page column 48-49 ;
反应条件
hydrazine in N,N-dimethyl-formamide T=110°C; 16 h;
参考文献
Li, Xiaoming; Chu, Sam; Feher, Victoria A.; Khalili, Mitra; Nie, Zhe; Margosiak, Stephen; Nikulin, Victor; Levin, James; Sprankle, Kelly G.; Tedder, Martina E.; Almassy, Robert; Appelt, Krzysztof; Yager, Kraig M.
Journal of Medicinal Chemistry, 2003 , vol. 46, # 26 p. 5663 - 5673
反应条件
sodium nitrate; sulfuric acid in water T=20°C;
参考文献
Iwakubo, Masayuki; Takami, Atsuya; Okada, Yuji; Kawata, Takehisa; Tagami, Yoshimichi; Ohashi, Hiroshi; Sato, Motoko; Sugiyama, Terumi; Fukushima, Kayoko; Iijima, Hiroshi
Bioorganic and Medicinal Chemistry, 2007 , vol. 15, # 1 p. 350 - 364
反应条件
1.1: sodium nitrite; H2SO4 / H2O / 1 h / 20 °C 1.2: 1.20 g / SnCl2 / H2O / 1 h / 0 °C 2.1: H2SO4; sodium nitrate / H2O / 1 h / 20 °C View Scheme
参考文献
Takami, Atsuya; Iwakubo, Masayuki; Okada, Yuji; Kawata, Takehisa; Odai, Hideharu; Takahashi, Nobuaki; Shindo, Kazutoshi; Kimura, Kaname; Tagami, Yoshimichi; Miyake, Mika; Fukushima, Kayoko; Inagaki, Masaki; Amano, Mutsuki; Kaibuchi, Kozo; Iijima, Hiroshi
Bioorganic and Medicinal Chemistry, 2004 , vol. 12, # 9 p. 2115 - 2137
反应条件
ethanol; hydrazine hydrate
参考文献
Borsche; Herbert
Justus Liebigs Annalen der Chemie, 1941 , vol. 546, p. 277,291
反应条件
hydrogenchloride; water; iron
参考文献
Takami, Atsuya; Iwakubo, Masayuki; Okada, Yuji; Kawata, Takehisa; Odai, Hideharu; Takahashi, Nobuaki; Shindo, Kazutoshi; Kimura, Kaname; Tagami, Yoshimichi; Miyake, Mika; Fukushima, Kayoko; Inagaki, Masaki; Amano, Mutsuki; Kaibuchi, Kozo; Iijima, Hiroshi
Bioorganic and Medicinal Chemistry, 2004 , vol. 12, # 9 p. 2115 - 2137
反应条件
1: 94 percent / concd. H2SO4; concd. HNO3 / 3 h / 0 - 20 °C
2: 61 percent / aq. (NH4)2S / ethanol / 80 °C
View Scheme
参考文献
Li, Xiaoming; Chu, Sam; Feher, Victoria A.; Khalili, Mitra; Nie, Zhe; Margosiak, Stephen; Nikulin, Victor; Levin, James; Sprankle, Kelly G.; Tedder, Martina E.; Almassy, Robert; Appelt, Krzysztof; Yager, Kraig M.
Journal of Medicinal Chemistry, 2003 , vol. 46, # 26 p. 5663 - 5673
反应条件
4-(N,N-dimethlyamino)pyridine; triethylamine in acetonitrile
3 h;
参考文献
SANOFI-AVENTIS
Patent: US2010/298377 A1, 2010 ;
Location in patent: Page/Page column 23 ;