1: Et3N, DMAP / CH2Cl2 / 24 h / Ambient temperature 2: DIPEA / CH2Cl2 / 24 h / Ambient temperature 3: 1.) Me2BBr / 1.) CH2Cl2, -78 deg C, 1 h; 2.) -78 deg C, 1 h 4: N-iodosuccinimide, trifluoromethanesulfonic acid / CH2Cl2; tetrahydrofuran / 0.03 h / 0 °C 5: NH2NH2*H2O / acetic acid; ethyl acetate; pyridine / 0.03 h / Ambient temperature View Scheme

1-methyl-1H-imidazole in 1,4-dioxane T=20°C; 1 h;

1: 64 percent / 1-methylimidazole / dioxane / 1 h / 20 °C 2: 34 percent / HNO3; H2SO4 / 0.33 h / cooling View Scheme

1: 64 percent / 1-methylimidazole / dioxane / 1 h / 20 °C 2: 21 percent / HNO3; H2SO4 / 0.33 h / cooling View Scheme