2-氨基-5-甲基苯甲酰胺合成路线 （共 11 条）
反应条件
hydrogen; palladium 10 on activated carbon in methanol T=20°C; P=760.051 Torr; 12 h;
参考文献
Takeda Pharmaceutical Company Limited
Patent: EP1953148 A1, 2008 ;
Location in patent: Page/Page column 130 ;
EP 1953148 A1
反应条件
ammonia; palladium monocarbide in tetrahydrofuran; methanol; N,N-dimethyl-formamide
参考文献
Takeda Chemical Industries, Ltd.
Patent: US5389641 A1, 1995 ;
US 5389641 A
反应条件
1: With 1,1'-carbonyldiimidazole in tetrahydrofuran T=20°C; 2 h; Inert atmosphere; 2: With ammonia in tetrahydrofuran; water 12 h; Inert atmosphere;
参考文献
Zhu, Yan-Ping; Fei, Zhuan; Liu, Mei-Cai; Jia, Feng-Cheng; Wu, An-Xin
Organic Letters, 2013 , vol. 15, # 2 p. 378 - 381
反应条件
1: 1.) SOCl2, 2.) NaOH, NH4OH / 1.) reflux, 20 min, 2.) THF 2: 96 percent / H2 / 5percent Pd/C / methanol / 24 h / 2280 Torr View Scheme
参考文献
Raffa, Demetrio; Maggio, Benedetta; Raimondi, Maria Valeria; Cusimano, Maria Grazia; Amico, Giandomenico; Carollo, Anna; Conaldi, Pier Giulio; Bai, Ruoli; Hamel, Ernest; Daidone, Giuseppe
European Journal of Medicinal Chemistry, 2013 , vol. 65, p. 427 - 435
反应条件
sodium hydroxide in tetrahydrofuran; dichloromethane; water
参考文献
American Cyanamid Company
Patent: US5001157 A1, 1991 ;
反应条件
ammonium hydroxide 4 h; Ambient temperature;
参考文献
Mohiuddin, Ghulam; Reddy, Padala Satyanarayana; Ahmed, Khalil; Ratnam, Chengalvala Venkata
Journal of Chemical Research, Miniprint, 1987 , # 7 p. 1839 - 1868
反应条件
1: ammonium hydroxide / acetonitrile / 8 h / |Reflux 2: tin(ll) chloride; hydrogenchloride / 25 h / 5 °C View Scheme
参考文献
Raffa, Demetrio; Maggio, Benedetta; Raimondi, Maria Valeria; Cusimano, Maria Grazia; Amico, Giandomenico; Carollo, Anna; Conaldi, Pier Giulio; Bai, Ruoli; Hamel, Ernest; Daidone, Giuseppe
European Journal of Medicinal Chemistry, 2013 , vol. 65, p. 427 - 435
反应条件
hydrogenchloride; tin
参考文献
Findeklee
Chemische Berichte, 1905 , vol. 38, p. 3555
反应条件
1: durch Nitrieren 2: tin; hydrochloric acid View Scheme
参考文献
Findeklee
Chemische Berichte, 1905 , vol. 38, p. 3555
反应条件
1: 12 N HCl / 20 °C 2: SOCl2 / dimethylformamide / Heating View Scheme
参考文献
Tobe, Masanori; Isobe, Yoshiaki; Tomizawa, Hideyuki; Matsumoto, Mitsuhiro; Obara, Fumihiro; Nagasaki, Takahiro; Hayashi, Hideya
Bioorganic and Medicinal Chemistry Letters, 2001 , vol. 11, # 4 p. 545 - 548
