(9ci)-4-氯-7-氟-1H-咪唑并[4,5-c]吡啶合成路线 （共 9 条）
反应条件
1: 3.6 g / TFA; aq. H2O2 / 20 h / 70 - 75 °C
2: 59 percent / conc. H2SO4; KNO3 / 2 h / 120 °C
3: 91 percent / H2 / Raney Ni / ethanol / 3 h / 2068.59 Torr
4: 83 percent / conc. H2SO4; KNO3 / 0 - 20 °C
5: 90 percent / conc. H2SO4 / 20 °C
6: 94 percent / H2 / Raney Ni / ethanol
View Scheme
参考文献
Liu; Luo; Mozdziesz; Lin; Dutschman; Gullen; Cheng; Sartorelli
Nucleosides, Nucleotides and Nucleic Acids, 2001 , vol. 20, # 12 p. 1975 - 2000
反应条件
1: 59 percent / conc. H2SO4; KNO3 / 2 h / 120 °C
2: 91 percent / H2 / Raney Ni / ethanol / 3 h / 2068.59 Torr
3: 83 percent / conc. H2SO4; KNO3 / 0 - 20 °C
4: 90 percent / conc. H2SO4 / 20 °C
5: 94 percent / H2 / Raney Ni / ethanol
View Scheme
参考文献
Liu; Luo; Mozdziesz; Lin; Dutschman; Gullen; Cheng; Sartorelli
Nucleosides, Nucleotides and Nucleic Acids, 2001 , vol. 20, # 12 p. 1975 - 2000
反应条件
1: 83 percent / conc. H2SO4; KNO3 / 0 - 20 °C
2: 90 percent / conc. H2SO4 / 20 °C
3: 94 percent / H2 / Raney Ni / ethanol
View Scheme
参考文献
Liu; Luo; Mozdziesz; Lin; Dutschman; Gullen; Cheng; Sartorelli
Nucleosides, Nucleotides and Nucleic Acids, 2001 , vol. 20, # 12 p. 1975 - 2000
反应条件
1: 90 percent / conc. H2SO4 / 20 °C
2: 94 percent / H2 / Raney Ni / ethanol
View Scheme
参考文献
Liu; Luo; Mozdziesz; Lin; Dutschman; Gullen; Cheng; Sartorelli
Nucleosides, Nucleotides and Nucleic Acids, 2001 , vol. 20, # 12 p. 1975 - 2000
反应条件
1: 91 percent / H2 / Raney Ni / ethanol / 3 h / 2068.59 Torr
2: 83 percent / conc. H2SO4; KNO3 / 0 - 20 °C
3: 90 percent / conc. H2SO4 / 20 °C
4: 94 percent / H2 / Raney Ni / ethanol
View Scheme
参考文献
Liu; Luo; Mozdziesz; Lin; Dutschman; Gullen; Cheng; Sartorelli
Nucleosides, Nucleotides and Nucleic Acids, 2001 , vol. 20, # 12 p. 1975 - 2000
反应条件
1: 94 percent / H2 / Raney Ni / ethanol
View Scheme
参考文献
Liu; Luo; Mozdziesz; Lin; Dutschman; Gullen; Cheng; Sartorelli
Nucleosides, Nucleotides and Nucleic Acids, 2001 , vol. 20, # 12 p. 1975 - 2000
反应条件
trimethylsilyl trifluoromethanesulfonate in dichloromethane
T=20°C;
参考文献
Liu; Luo; Mozdziesz; Lin; Dutschman; Gullen; Cheng; Sartorelli
Nucleosides, Nucleotides and Nucleic Acids, 2001 , vol. 20, # 12 p. 1975 - 2000
反应条件
1: CF3SO3Si(CH3)3 / CH2Cl2 / 20 °C
View Scheme
参考文献
Liu; Luo; Mozdziesz; Lin; Dutschman; Gullen; Cheng; Sartorelli
Nucleosides, Nucleotides and Nucleic Acids, 2001 , vol. 20, # 12 p. 1975 - 2000
参考文献
Liu; Luo; Mozdziesz; Lin; Dutschman; Gullen; Cheng; Sartorelli
Nucleosides, Nucleotides and Nucleic Acids, 2001 , vol. 20, # 12 p. 1975 - 2000
