formic acid in toluene 2 h; Reflux;

1.1: magnesium / tetrahydrofuran / |Reflux 1.2: 20 °C / |Reflux 2.1: pyridine; 1,8-diazabicyclo[5.4.0]undec-7-ene; trichlorophosphate / 0 - 80 °C 3.1: palladium 10 on activated carbon; hydrogen / methanol; ethyl acetate / 5 h / 30003 Torr 4.1: sulfuric acid / tetrahydrofuran; water / 1.5 h View Scheme

1.1: magnesium / tetrahydrofuran / |Reflux 1.2: 20 °C / |Reflux 2.1: pyridine; 1,8-diazabicyclo[5.4.0]undec-7-ene; trichlorophosphate / 0 - 80 °C 3.1: palladium 10 on activated carbon; hydrogen / methanol; ethyl acetate / 5 h / 30003 Torr 4.1: sulfuric acid / tetrahydrofuran; water / 1.5 h View Scheme

(i) CF3CO2H, (ii) H2, Pd-C; Multistep reaction;

1: (i), (ii) CrO3, H2SO4 2: (i) CF3CO2H, (ii) H2, Pd-C View Scheme

1: (i), (ii) CrO3, H2SO4 2: (i) CF3CO2H, (ii) H2, Pd-C View Scheme