4-羟基-[1,1-联苯]-4-羧酸甲酯合成路线 （共 23 条）
反应条件
1: Mg, C2H5Br / diethyl ether
2: 48percent HBr / acetic acid
3: H(+) / toluene
View Scheme
参考文献
Surendranath, V.; Fishel, D. L.; Vries, A de; Mahmood, R.; Johnson, D. L.
Molecular Crystals and Liquid Crystals (1969-1991), 1985 , vol. 131, p. 1 - 8
反应条件
1: KOH / ethanol
2: K2CO3 / acetone
3: Mg, C2H5Br / diethyl ether
4: 48percent HBr / acetic acid
5: H(+) / toluene
View Scheme
参考文献
Surendranath, V.; Fishel, D. L.; Vries, A de; Mahmood, R.; Johnson, D. L.
Molecular Crystals and Liquid Crystals (1969-1991), 1985 , vol. 131, p. 1 - 8
反应条件
1: 100 percent / K2CO3 / butan-2-one / 24 h / Heating
2: 98 percent / aq. LiOH / tetrahydrofuran / 20 °C
3: 99 percent / SOCl2 / 4 h / 90 °C
4: Hunig's base / CH2Cl2 / 0 °C
View Scheme
参考文献
Faghih, Ramin; Dwight, Wesley; Pan, Jia Bao; Fox, Gerard B.; Krueger, Kathy M.; Esbenshade, Timothy A.; McVey, Jill M.; Marsh, Kennan; Bennani, Youssef L.; Hancock, Arthur A.
Bioorganic and Medicinal Chemistry Letters, 2003 , vol. 13, # 7 p. 1325 - 1328
