2,3-二氢苯并呋喃-5-醇合成路线 （共 22 条）
反应条件
hydrogen; palladium 10 on activated carbon in ethanol P=2585.81 Torr; 19 h;
参考文献
CONNOLLY, PETER J.; Lin, Shu-Chen; Macielag, Mark J.; Zhang, Yue-Mei
Patent: US2011/105527 A1, 2011 ;
Location in patent: Page/Page column 18 ;
反应条件
1: With boron tribromide in dichloromethane T=-78 - 20°C; 2: With sodium hydrogencarbonate in dichloromethane
参考文献
FOREST LABORATORIES HOLDINGS LIMITED; SARMA, Pakala Kumara, Savithru; ACHARYA, Vinod, Parameshwaran; KASIBHATLA, Srinivas, Rao; TIWARI, Atul; REDDY, Vantaddu, Nagarjuna; BISCHOFF, Alexander
Patent: WO2010/127208 A1, 2010 ;
Location in patent: Page/Page column 60-61 ;
反应条件
formic acid; dihydrogen peroxide in dichloromethane 3 h; Reflux;
参考文献
Endura S.p.a.; Rothamsted Research Limited
Patent: EP2289889 A1, 2011 ;
Location in patent: Page/Page column 15 ;
反应条件
2-cyclohexene-1,4-dione; pyridinium p-toluenesulfonate in toluene 3 h; Heating;
参考文献
Benbow; Katoch-Rouse
Journal of Organic Chemistry, 2001 , vol. 66, # 15 p. 4965 - 4972
反应条件
potassium carbonate in acetone 56 h; Heating;
参考文献
Nichols; Snyder; Oberlender; Johnson; Huang
Journal of Medicinal Chemistry, 1991 , vol. 34, # 1 p. 276 - 281
反应条件
1: PBr3 2: BBr3 / CH2Cl2 / -78 °C 3: K2CO3 / acetone / 56 h / Heating View Scheme
参考文献
Nichols; Snyder; Oberlender; Johnson; Huang
Journal of Medicinal Chemistry, 1991 , vol. 34, # 1 p. 276 - 281
反应条件
1: 100 percent / diborane / tetrahydrofuran 2: PBr3 3: BBr3 / CH2Cl2 / -78 °C 4: K2CO3 / acetone / 56 h / Heating View Scheme
参考文献
Nichols; Snyder; Oberlender; Johnson; Huang
Journal of Medicinal Chemistry, 1991 , vol. 34, # 1 p. 276 - 281
反应条件
1: BBr3 / CH2Cl2 / -78 °C 2: K2CO3 / acetone / 56 h / Heating View Scheme
参考文献
Nichols; Snyder; Oberlender; Johnson; Huang
Journal of Medicinal Chemistry, 1991 , vol. 34, # 1 p. 276 - 281
反应条件
1.1: BBr3*Me2S complex / anhydrous dichloroethane / 4 h / Inert atmosphere; Reflux 1.2: 0.33 h 2.1: hydrogen / palladium 10 on activated carbon / ethanol / 19 h / 2585.81 Torr View Scheme
参考文献
CONNOLLY, PETER J.; Lin, Shu-Chen; Macielag, Mark J.; Zhang, Yue-Mei
Patent: US2011/105527 A1, 2011 ;
反应条件
boron trichloride in dichloromethane 2 h; -20 deg to r.t.;
参考文献
Hammond; Kopka; Zambias; Caldwell; Boger; Baker; Bach; Luell; MacIntyre
Journal of Medicinal Chemistry, 1989 , vol. 32, # 5 p. 1006 - 1020
