2-羟基-6-苄氧基苯乙酮合成路线 （共 14 条）
反应条件
1: 85 percent / 60percent aq. NaOH / 20 h / Ambient temperature 2: 89 percent / DMSO, I2 / 2 h / Heating View Scheme
参考文献
Pinto, Diana C. G. A.; Silva, Artur M. S.; Cavaleiro, Jose A. S.
Journal of Heterocyclic Chemistry, 1996 , vol. 33, # 6 p. 1887 - 1893
反应条件
1: 85.4 percent / pyridine / 12 h / 20 °C 2: 90.9 percent / potassium hydroxide / dimethylsulfoxide / 2 h / 20 °C 3: 93.2 percent / p-toluenesulfonic acid monohydrate / dimethylsulfoxide / 90 °C 4: 51.1 percent / hydrogen bromide / acetic acid / Heating View Scheme
参考文献
Pinto, Diana C. G. A.; Silva, Artur M. S.; Cavaleiro, Jose A. S.
Journal of Heterocyclic Chemistry, 1996 , vol. 33, # 6 p. 1887 - 1893
反应条件
potassium carbonate; potassium iodide in acetone
Heating;
参考文献
Smith, Jeffrey A.; Maloney, David J.; Hecht, Sidney M.; Lannigan, Deborah A.
Bioorganic and Medicinal Chemistry, 2007 , vol. 15, # 14 p. 5018 - 5034
反应条件
potassium carbonate in N,N-dimethyl-formamide
24 h;
参考文献
Zhao, Xiaolong; Liu, Jie; Xie, Zhixiang; Li, Ying
Synthesis (Germany), 2012 , vol. 44, # 14 art. no. SS-2012-H0237-OP, p. 2217 - 2224
反应条件
potassium carbonate in N,N-dimethyl-formamide
T=80°C; 3 h;
参考文献
Brunskole, Mojca; Stefane, Bogdan; Zorko, Karmen; Anderluh, Marko; Stojan, Jure; Lanisnik Rizner, Tea; Gobec, Stanislav
Bioorganic and Medicinal Chemistry, 2008 , vol. 16, # 11 p. 5881 - 5889
反应条件
in dichloromethane; acetone
参考文献
Pharmacia and Upjohn Company
Patent: US5703075 A1, 1997 ;
反应条件
potassium carbonate in acetone
Heating;
参考文献
Lee, Tsung T.; Starratt, Alvin N.; Jevnikar, John J.
Phytochemistry (Elsevier), 1982 , vol. 21, # 3 p. 517 - 524
反应条件
potassium carbonate; acetone
参考文献
Baker; Brown; Scott
Journal of the Chemical Society, 1939 , p. 1922,1926
反应条件
1: potassium hydroxide / methanol / 19 h / 85 °C
2: iodine / dimethyl sulfoxide / 140 °C
3: acetic acid / water / 24 h / 110 °C
View Scheme
参考文献
Kralj, Ana; Nguyen, Mai-Thao; Tschammer, Nuska; Ocampo, Nicolette; Gesiotto, Quinto; Heinrich, Markus R.; Phanstiel, Otto
Journal of Medicinal Chemistry, 2013 , vol. 56, # 12 p. 5019 - 5032
反应条件
1: 1.) lithium diisopropylamide, 2.) hexamethylphosphoric triamide / 1.) THF, -78 deg C, 2 h, 2.) -78 deg C, 1 h, then -15 deg C, 30 min
2: 86 percent / p-toluenesulfonic acid / benzene / 1 h / Heating
3: 89 percent / hydrogen / 10 percent Pd-C / acetone / 6 h / 2574.3 Torr / Ambient temperature
View Scheme
参考文献
Tsuda; Hosoi; Goto
Chemical and Pharmaceutical Bulletin, 1991 , vol. 39, # 1 p. 18 - 22
