2,3-二氢-1H-茚-4-羧酸合成路线 （共 24 条）
反应条件
1: NaOH / 1) 1h reflux with NaOH 2) concentrated HCl
2: SOCl2
3: 1) BF3*THF 2) NaOH, 30percent H2O2 / 2) at 55-60 deg C for 90 min
4: 88 percent / triethylamine / CH2Cl2 / 2.5 h / Ambient temperature
5: 100 percent / LiBr / dimethylformamide
6: 80 percent / Mg / tetrahydrofuran / 48 h / Heating
7: 67 percent / 4.5M HCl / 18 h / Heating
View Scheme
参考文献
Meyers, A. I.; Reuman, Michael; Gabel, Richard A.
Journal of Organic Chemistry, 1981 , vol. 46, # 4 p. 783 - 788
反应条件
1: 1) BF3*THF 2) NaOH, 30percent H2O2 / 2) at 55-60 deg C for 90 min
2: 88 percent / triethylamine / CH2Cl2 / 2.5 h / Ambient temperature
3: 100 percent / LiBr / dimethylformamide
4: 80 percent / Mg / tetrahydrofuran / 48 h / Heating
5: 67 percent / 4.5M HCl / 18 h / Heating
View Scheme
参考文献
Meyers, A. I.; Reuman, Michael; Gabel, Richard A.
Journal of Organic Chemistry, 1981 , vol. 46, # 4 p. 783 - 788
反应条件
1: 88 percent / triethylamine / CH2Cl2 / 2.5 h / Ambient temperature
2: 100 percent / LiBr / dimethylformamide
3: 80 percent / Mg / tetrahydrofuran / 48 h / Heating
4: 67 percent / 4.5M HCl / 18 h / Heating
View Scheme
参考文献
Meyers, A. I.; Reuman, Michael; Gabel, Richard A.
Journal of Organic Chemistry, 1981 , vol. 46, # 4 p. 783 - 788
反应条件
1: 80 percent / Mg / tetrahydrofuran / 48 h / Heating
2: 67 percent / 4.5M HCl / 18 h / Heating
View Scheme
参考文献
Meyers, A. I.; Reuman, Michael; Gabel, Richard A.
Journal of Organic Chemistry, 1981 , vol. 46, # 4 p. 783 - 788
反应条件
1: 100 percent / LiBr / dimethylformamide
2: 80 percent / Mg / tetrahydrofuran / 48 h / Heating
3: 67 percent / 4.5M HCl / 18 h / Heating
View Scheme
参考文献
Meyers, A. I.; Reuman, Michael; Gabel, Richard A.
Journal of Organic Chemistry, 1981 , vol. 46, # 4 p. 783 - 788
反应条件
1: NaH / 1) 20 min at 0 deg C 2) reflux for 12 h
2: NaOH / 1) 1h reflux with NaOH 2) concentrated HCl
3: SOCl2
4: 1) BF3*THF 2) NaOH, 30percent H2O2 / 2) at 55-60 deg C for 90 min
5: 88 percent / triethylamine / CH2Cl2 / 2.5 h / Ambient temperature
6: 100 percent / LiBr / dimethylformamide
7: 80 percent / Mg / tetrahydrofuran / 48 h / Heating
8: 67 percent / 4.5M HCl / 18 h / Heating
View Scheme
参考文献
Meyers, A. I.; Reuman, Michael; Gabel, Richard A.
Journal of Organic Chemistry, 1981 , vol. 46, # 4 p. 783 - 788
反应条件
1: 57.3 percent / CH2Cl2 / 2 h
2: 63.8 percent / AlCl3 / CCl4 / 2 h / Ambient temperature
3: 70.2 percent / AlCl3 / toluene / 120 h / Ambient temperature
4: 84 percent / aq. NaOBr / dioxane / 1.) ice-cooling, 10 h, 2.) r.t., 5 h
View Scheme
参考文献
Melmer; Neudeck
Monatshefte fur Chemie, 1996 , vol. 127, # 3 p. 275 - 290
反应条件
1: 63.8 percent / AlCl3 / CCl4 / 2 h / Ambient temperature
2: 70.2 percent / AlCl3 / toluene / 120 h / Ambient temperature
3: 84 percent / aq. NaOBr / dioxane / 1.) ice-cooling, 10 h, 2.) r.t., 5 h
View Scheme
参考文献
Melmer; Neudeck
Monatshefte fur Chemie, 1996 , vol. 127, # 3 p. 275 - 290
反应条件
hydrogenchloride; mercury dichloride; zinc in methanol
10 h; Heating;
参考文献
Subba Rao; Hariprakasha; Girija; Vijaya Bhaskar
Journal of the Indian Chemical Society, 1997 , vol. 74, # 11-12 p. 961 - 969
反应条件
1: 65.6 percent / NaCl, AlCl3 / 2 h / 160 °C
2: Zn, HgCl2, aq.HCl / methanol / 10 h / Heating
View Scheme
参考文献
Subba Rao; Hariprakasha; Girija; Vijaya Bhaskar
Journal of the Indian Chemical Society, 1997 , vol. 74, # 11-12 p. 961 - 969
