(S)-(+)-1-苯基-1,2-乙二醇对甲苯磺酸酯合成路线 （共 33 条）
反应条件
1.1: 40 percent / NaBH4 / ethanol / 2 h / 20 °C 2.1: Et3N; DMAP / CH2Cl2 / 20 °C 2.2: 64.2 percent / TFA / CH2Cl2 / 2 h / 20 °C View Scheme
参考文献
Madhusudhan; Om Reddy; Ramanatham; Dubey
Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2004 , vol. 43, # 12 p. 2719 - 2723
反应条件
1: 85 percent / NaI / acetone / 4 h / Heating 2: 93 percent / DBU / CH2Cl2 / 0.5 h / Ambient temperature 3: 76 percent / pyridine / organotin phosphate condensates (OPC) / Heating View Scheme
参考文献
Otera, Junzo; Niibo, Yoshihisa; Nozaki, Hitosi
Tetrahedron, 1991 , vol. 47, # 36 p. 7625 - 7634
反应条件
in dichloromethane T=40°C; 28 h;
参考文献
Pfizer Inc.
Patent: US2009/318440 A1, 2009 ;
Location in patent: Page/Page column 61-62 ;
反应条件
lithium aluminium tetrahydride in tetrahydrofuran 3 h; Ambient temperature;
参考文献
Mangold, James B.; Abdel-Monem, Mahmoud M.
Journal of Medicinal Chemistry, 1983 , vol. 26, # 1 p. 66 - 71
反应条件
sodium hydroxide in diethyl ether T=20°C; 3 h;
参考文献
Cho, Byung Tae; Yang, Weon Ki; Choi, Ok Kyung
Journal of the Chemical Society, Perkin Transactions 1, 2001 , # 10 p. 1204 - 1211
反应条件
4-(N,N-dimethlyamino)pyridine; potassium cyanide in methanol T=20°C; 23 h;
参考文献
Helvetica Chimica Acta, , vol. 86, # 3 p. 644 - 656
反应条件
1: 39.5 percent / KCN; DMAP / methanol / 23 h / 20 °C 2: 57.4 percent / aq. NaOH; H2O2 / 6.5 h / 20 °C View Scheme
参考文献
Meisterhans, Christian; Linden, Anthony; Hesse, Manfred
Helvetica Chimica Acta, 2003 , vol. 86, # 3 p. 644 - 656
反应条件
1: K2CO3 / methanol / 1 h / 4 °C 2: NaN3 3: 127 mg / H2 / PtO2 / methanol / 2 h / 20 °C / 750.06 Torr View Scheme
参考文献
Uccello-Barretta, Gloria; Cuzzola, Angela; Balzano, Federica; Menicagli, Rita; Iuliano, Anna; Salvadori, Piero
Journal of Organic Chemistry, 1997 , vol. 62, # 4 p. 827 - 835
反应条件
1: 90 percent / ethanol; H2O / 24 h / 20 °C 2: 96 percent / borane dimethyl sulfide complex; methyl sulfide / tetrahydrofuran / 2.5 h / Heating 3: 90 percent / sodium hydride / dimethylsulfoxide / 55 - 90 °C View Scheme
参考文献
Pandey, Rajesh Kumar; Fernandes, Rodney A.; Kumar, Pradeep
Tetrahedron Letters, 2002 , vol. 43, # 25 p. 4425 - 4426
反应条件
1.1: 90 percent / aq. ethanol / 24 h / 20 °C 2.1: 96 percent / BH3*SMe2 / tetrahydrofuran / 2 h / Heating 3.1: NaH / dimethylsulfoxide / 0.5 h / 55 °C 3.2: 90 percent / dimethylsulfoxide / 1 h / 90 °C 4.1: aq. K2CO3 / CH2Cl2 / 0.5 h 5.1: LiAlH4 / tetrahydrofuran / 2 h / 65 °C 6.1: 95 percent / HCl / diethyl ether View Scheme
参考文献
Pandey, Rajesh Kumar; Fernandes, Rodney A.; Kumar, Pradeep
Tetrahedron Letters, 2002 , vol. 43, # 25 p. 4425 - 4426
