8-氯-10-[3-(二甲基氨基)丙基]-10H-吩噻嗪-1-醇合成路线 （共 12 条）
反应条件
1: 1,2-dichloro-benzene / (thionation)
2: K2CO3 / dimethylformamide
3: NaH / toluene / 10 h / Heating
4: aq. HCl / 3 h / Heating
View Scheme
参考文献
Nodiff,E.A. et al.
Journal of Heterocyclic Chemistry, 1968 , vol. 5, p. 165 - 177
反应条件
1: ZnCl2
2: 1,2-dichloro-benzene / (thionation)
3: K2CO3 / dimethylformamide
4: NaH / toluene / 10 h / Heating
5: aq. HCl / 3 h / Heating
View Scheme
参考文献
Nodiff,E.A. et al.
Journal of Heterocyclic Chemistry, 1968 , vol. 5, p. 165 - 177
反应条件
1: ZnCl2
2: 1,2-dichloro-benzene / (thionation)
3: K2CO3 / dimethylformamide
4: NaH / toluene / 10 h / Heating
5: aq. HCl / 3 h / Heating
View Scheme
参考文献
Nodiff,E.A. et al.
Journal of Heterocyclic Chemistry, 1968 , vol. 5, p. 165 - 177
反应条件
1: K2CO3 / dimethylformamide
2: NaH / toluene / 10 h / Heating
3: aq. HCl / 3 h / Heating
View Scheme
参考文献
Nodiff,E.A. et al.
Journal of Heterocyclic Chemistry, 1968 , vol. 5, p. 165 - 177
反应条件
1: NaH / toluene / 10 h / Heating
2: aq. HCl / 3 h / Heating
View Scheme
参考文献
Nodiff,E.A. et al.
Journal of Heterocyclic Chemistry, 1968 , vol. 5, p. 165 - 177
反应条件
1: (i) SO3, H2SO4, (ii) HNO3
2: KOH / ethanol
3: NaOEt / ethanol
4: SnCl2, aq. HCl
5: (cyclisation)
6: NaH / toluene / 10 h / Heating
7: aq. HCl / 3 h / Heating
View Scheme
参考文献
Nodiff,E.A. et al.
Journal of Heterocyclic Chemistry, 1968 , vol. 5, p. 165 - 177
反应条件
1: KOH / ethanol
2: NaOEt / ethanol
3: SnCl2, aq. HCl
4: (cyclisation)
5: NaH / toluene / 10 h / Heating
6: aq. HCl / 3 h / Heating
View Scheme
参考文献
Nodiff,E.A. et al.
Journal of Heterocyclic Chemistry, 1968 , vol. 5, p. 165 - 177
反应条件
1: NaOEt / ethanol
2: SnCl2, aq. HCl
3: (cyclisation)
4: NaH / toluene / 10 h / Heating
5: aq. HCl / 3 h / Heating
View Scheme
参考文献
Nodiff,E.A. et al.
Journal of Heterocyclic Chemistry, 1968 , vol. 5, p. 165 - 177
反应条件
1: SnCl2, aq. HCl
2: (cyclisation)
3: NaH / toluene / 10 h / Heating
4: aq. HCl / 3 h / Heating
View Scheme
参考文献
Nodiff,E.A. et al.
Journal of Heterocyclic Chemistry, 1968 , vol. 5, p. 165 - 177
反应条件
1: 1,2-dichloro-benzene / (thionation)
2: NaH / toluene / 10 h / Heating
3: aq. HCl / 3 h / Heating
View Scheme
参考文献
Nodiff,E.A. et al.
Journal of Heterocyclic Chemistry, 1968 , vol. 5, p. 165 - 177
