1-(3-异丙基苯基)乙酮合成路线 （共 13 条）
反应条件
1: 1-bromo-3-(propan-2-yl)benzene With n-butyllithium in tetrahydrofuran
T=-60°C; 0.5 h;
2: N,O-dimethylacetohydroxamic acid in tetrahydrofuran
T=-30°C; 3 h;
参考文献
RIPKA, Amy, S.; SAUNDERS, Jeffrey, O.; KAMENECKA, Theodore, Mark; GRIFFIN, Patrick, R.
Patent: WO2013/78233 A1, 2013 ;
Location in patent: Page/Page column 62 ;
反应条件
bis(triphenylphosphine)palladium(II)-chloride in N,N-dimethyl-formamide
T=60°C; 8 h;
参考文献
Dalton, Audra M.; Zhang, Yongjun; Davie, Christopher P.; Danheiser, Rick L.
Organic Letters, 2002 , vol. 4, # 15 p. 2465 - 2468
反应条件
hydrogen; palladium on activated charcoal; 5 percent palladium-carbon in ethyl acetate
参考文献
Abate, Agnese; Brenna, Elisabetta; Dei Negri, Claudia; Fuganti, Claudio; Serra, Stefano
Tetrahedron Asymmetry, 2002 , vol. 13, # 8 p. 899 - 904
反应条件
in tetrahydrofuran
T=0 - 20°C; 2 h;
参考文献
HENGRUI (USA), LTD.; SMITH, Emilie, D.; FITZGERALD, Mark, E.; JIANG, Rong; ATKINSON, Robert, N.; VEAL, James, M.; HUANG, Kenneth, H.
Patent: WO2013/49585 A1, 2013 ;
Location in patent: Page/Page column 42 ;
反应条件
1.1: ozone / CH2Cl2; methanol / -78 °C
1.2: 45 percent / triphenylphosphane
2.1: 98 percent / H2 / 5 percent Pd/C / ethyl acetate
View Scheme
参考文献
Abate, Agnese; Brenna, Elisabetta; Dei Negri, Claudia; Fuganti, Claudio; Serra, Stefano
Tetrahedron Asymmetry, 2002 , vol. 13, # 8 p. 899 - 904
参考文献
Campbell; Spaeth
Journal of the American Chemical Society, 1959 , vol. 81, p. 5933,5934
反应条件
carbon disulfide; aluminium trichloride
参考文献
Campbell; Spaeth
Journal of the American Chemical Society, 1959 , vol. 81, p. 5933,5934
反应条件
aluminium trichloride; acetyl chloride in dichloromethane
at 25°C;;
参考文献
Gmelin Handbook: Cr: Org.Verb., 1.6.1.2.1.2, page 190 - 200
反应条件
1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; 4-(N,N-dimethlyamino)pyridine / dichloromethane / 20 °C
2: tetrahydrofuran / 2 h / 0 - 20 °C
View Scheme
参考文献
HENGRUI (USA), LTD.; SMITH, Emilie, D.; FITZGERALD, Mark, E.; JIANG, Rong; ATKINSON, Robert, N.; VEAL, James, M.; HUANG, Kenneth, H.
Patent: WO2013/49585 A1, 2013 ;
反应条件
sodium hydroxide in water; isobutyl methylketone
T=90°C; Heating / reflux;
参考文献
Indspec Chemical Corporation
Patent: US6350921 B1, 2002 ;
Location in patent: Example 3 ;
