反应条件
1.1: n-BuLi / tetrahydrofuran; hexane / 0.25 h / -78 - -75 °C 1.2: 86 percent / tetrahydrofuran; hexane / 2 h / -78 °C 2.1: NaH / dimethylformamide / 0.5 h 2.2: 95 percent / Bu4NI / dimethylformamide / 16 h / 20 °C 3.1: NaH / tetrahydrofuran / 0.5 h / 0 °C 3.2: 83 percent / tetrahydrofuran / 4 h / Heating 4.1: 99 percent / CF3CO2H; CF3SO3H / CH2Cl2 / 3 h / 20 °C 5.1: i-Pr2NEt / dioxane / 12 h / Heating View Scheme
参考文献
Lombardo, Louis J.; Lee, Francis Y.; Chen, Ping; Norris, Derek; Barrish, Joel C.; Behnia, Kamelia; Castaneda, Stephen; Cornelius, Lyndon A. M.; Das, Jagabandhu; Doweyko, Arthur M.; Fairchild, Craig; Hunt, John T.; Inigo, Ivan; Johnston, Kathy; Kamath, Amrita; Kan, David; Klei, Herbert; Marathe, Punit; Pang, Suhong; Peterson, Russell; Pitt, Sidney; Schieven, Gary L.; Schmidt, Robert J.; Tokarski, John; Wen, Mei-Li; Wityak, John; Borzilleri, Robert M.
Journal of Medicinal Chemistry, 2004 , vol. 47, # 27 p. 6658 - 6661