3-氟-4-(2-吗啉-4-基-乙氧基)苯胺合成路线 （共 6 条）
反应条件
hydrogen; palladium on activated charcoal in methanol
5 h; Inert atmosphere;
参考文献
AURIGENE DISCOVERY TECHNOLOGIES LIMITED; SENGUPTA, Saumitra; RAJAGOPALAN, Srinivasan; BELAVAGI, Ningaraddi; RAMACHANDRA, Muralidhara
Patent: WO2012/59932 A1, 2012 ;
Location in patent: Page/Page column 120 ;
WO 2012/059932 A1
反应条件
1: K2CO3 / dimethylformamide / 48 h / 20 °C
2: Et3N / CH2Cl2 / 4 h / 0 °C
3: Et3N / dimethylformamide / 12 h / 80 °C
4: H2 / Pd/C / tetrahydrofuran / 14 h
View Scheme
参考文献
Selvakumar; Raheem, Mohammed A.; Khera, Manoj Kumar; Rajale, Trideep V.; Kumar, Magadi Sitaram; Kandepu, Sreenivas; Das, Jagattaran; Rajagopalan; Iqbal, Javed; Trehan, Sanjay
Bioorganic and Medicinal Chemistry Letters, 2003 , vol. 13, # 23 p. 4169 - 4172
反应条件
1: Et3N / CH2Cl2 / 4 h / 0 °C
2: Et3N / dimethylformamide / 12 h / 80 °C
3: H2 / Pd/C / tetrahydrofuran / 14 h
View Scheme
参考文献
Selvakumar; Raheem, Mohammed A.; Khera, Manoj Kumar; Rajale, Trideep V.; Kumar, Magadi Sitaram; Kandepu, Sreenivas; Das, Jagattaran; Rajagopalan; Iqbal, Javed; Trehan, Sanjay
Bioorganic and Medicinal Chemistry Letters, 2003 , vol. 13, # 23 p. 4169 - 4172
反应条件
1: Et3N / dimethylformamide / 12 h / 80 °C
2: H2 / Pd/C / tetrahydrofuran / 14 h
View Scheme
参考文献
Selvakumar; Raheem, Mohammed A.; Khera, Manoj Kumar; Rajale, Trideep V.; Kumar, Magadi Sitaram; Kandepu, Sreenivas; Das, Jagattaran; Rajagopalan; Iqbal, Javed; Trehan, Sanjay
Bioorganic and Medicinal Chemistry Letters, 2003 , vol. 13, # 23 p. 4169 - 4172
反应条件
1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 0 °C
1.2: 2 h
2.1: hydrogen / palladium on activated charcoal / methanol / 5 h / Inert atmosphere
View Scheme
参考文献
AURIGENE DISCOVERY TECHNOLOGIES LIMITED; SENGUPTA, Saumitra; RAJAGOPALAN, Srinivasan; BELAVAGI, Ningaraddi; RAMACHANDRA, Muralidhara
Patent: WO2012/59932 A1, 2012 ;
WO 2012/059932 A1
反应条件
1: caesium carbonate / N,N-dimethyl-formamide / 12 h / 75 °C
2: hydrogen; palladium 10 on activated carbon / tetrahydrofuran / 20 °C
View Scheme
参考文献
SUNSHINE LAKE PHARMA CO., LTD.; ZHANG, Yingjun; ZHANG, Jiancun; WANG, Xiaojun; LIN, Runfeng; CAO, Shengtian; WANG, Zhaohe; LI, Jing
Patent: WO2014/12360 A1, 2014 ;
