7-硝基-3,4-二氢-2H-1-萘酮合成路线 （共 23 条）
反应条件
sulfuric acid; potassium nitrate T=15°C; 1 h;
参考文献
MITSUBISHI PHARMA CORPORATION
Patent: WO2004/87124 A1, 2004 ;
Location in patent: Page/Page column 47-48 ;
WO 2004/087124 A1
反应条件
sulfuric acid; nitric acid T=0°C; 1 h;
参考文献
Riedel,J. D.
Patent: DE408665 ;
Fortschr. Teerfarbenfabr. Verw. Industriezweige, vol. 14, p. 466
反应条件
sulfuric acid; nitric acid T=-10°C;
参考文献
v. Braun
Justus Liebigs Annalen der Chemie, 1927 , vol. 451, p. 53
反应条件
1: aqueous NaOH / 60 - 70 °C 2: anhydrous sulfuric acid; sulfuric acid; nitric acid / -20 - -15 °C View Scheme
参考文献
Vesely; Stursa
Collection of Czechoslovak Chemical Communications, 1933 , vol. 5, p. 170,177
参考文献
v. Braun
Justus Liebigs Annalen der Chemie, 1927 , vol. 451, p. 53
Full Text Show Details
Riedel,J. D.
Patent: DE408665 ;
Fortschr. Teerfarbenfabr. Verw. Industriezweige, vol. 14, p. 466
参考文献
Riedel,J. D.
Patent: DE408665 ;
Fortschr. Teerfarbenfabr. Verw. Industriezweige, vol. 14, p. 466
反应条件
1: hydroxylamine hydrochloride; sodium acetate / water; ethanol / 1 h / |Reflux 2: polyphosphoric acid / 16 h / 125 °C 3: sodium hydride / N,N-dimethyl-formamide; mineral oil / 16 h / 20 °C 4: palladium 10 on activated carbon; ammonium formate / methanol / 0.08 h / -8 °C / |Microwave irradiation View Scheme
参考文献
SANOFI; CARRY, Jean-Christophe; CHATREAUX, Fabienne; DEPRETS, Stéphanie; DUCLOS, Olivier; LEROY, Vincent; MALLART, Sergio; MELON-MANGUER, Dominique; MENDEZ-PEREZ, Maria; VERGNE, Fabrice
Patent: WO2013/150036 A1, 2013 ;
反应条件
ammonium acetate; sodium cyanoborohydride in methanol
参考文献
Gross, Michael F.; Castle, Neil A.; Zou, Anruo; Wickenden, Alan D.; Yu, Weifeng; Spear, Kerry L.
Bioorganic and Medicinal Chemistry Letters, 2009 , vol. 19, # 11 p. 3063 - 3066
反应条件
sodium hydroxide; sodium azide in acetic acid
参考文献
Hoffmann-La Roche Inc.
Patent: US5216148 A1, 1993 ;
反应条件
1: hydroxylamine hydrochloride; sodium acetate / water; ethanol / 1 h / |Reflux 2: polyphosphoric acid / 16 h / 125 °C View Scheme
参考文献
SANOFI; CARRY, Jean-Christophe; CHATREAUX, Fabienne; DEPRETS, Stéphanie; DUCLOS, Olivier; LEROY, Vincent; MALLART, Sergio; MELON-MANGUER, Dominique; MENDEZ-PEREZ, Maria; VERGNE, Fabrice
Patent: WO2013/150036 A1, 2013 ;
