D-3-(五氟苯基)丙氨酸合成路线 （共 4 条）
反应条件
1: 64 percent / LDA / tetrahydrofuran; hexane / from -60 degC to room temp. 2: 1.) trifluoroacetic acid; 2.) DOWEX 50 Wx 8 cation exchange resin / 1.) CH2Cl2, overnight; 2.) AcOH, 0.75 N HCl, 100 degC, 18 h View Scheme
参考文献
Fitzi, Robert; Seebach, Dieter
Tetrahedron, 1988 , vol. 44, # 17 p. 5277 - 5292
反应条件
1: 84 percent / NaHCO3 / acetone; H2O / 3 h / -10 - 25 °C 3: 6 N aq. HCl / 7 h / 70 - 80 °C View Scheme
参考文献
Soloshonok, V. A.; Shvyadas, V. K.; Kukhar, V. P.; Galaev, I. Yu.; Kozlova, E. V.; Svistunova, N. Yu.
Russian Journal of Bioorganic Chemistry, 1993 , vol. 19, # 4 p. 236 - 240
Bioorganicheskaya Khimiya, 1993 , vol. 19, # 4 p. 478 - 483
反应条件
DOWEX 50 Wx 8 cation exchange resin; trifluoroacetic acid 1.) CH2Cl2, overnight; 2.) AcOH, 0.75 N HCl, 100 degC, 18 h; Yield given. Multistep reaction;
参考文献
Fitzi, Robert; Seebach, Dieter
Tetrahedron, 1988 , vol. 44, # 17 p. 5277 - 5292
反应条件
2: 6 N aq. HCl / 7 h / 70 - 80 °C View Scheme
参考文献
Soloshonok, V. A.; Shvyadas, V. K.; Kukhar, V. P.; Galaev, I. Yu.; Kozlova, E. V.; Svistunova, N. Yu.
Russian Journal of Bioorganic Chemistry, 1993 , vol. 19, # 4 p. 236 - 240
Bioorganicheskaya Khimiya, 1993 , vol. 19, # 4 p. 478 - 483
