1-(4-溴苯基)-2-氟乙酮合成路线 （共 17 条）
反应条件
1,3-dimethyl-2-phenyl-2,3-dihydro-1H-benzo[d]imidazole; azobisisobutyronitrile in acetonitrile T=61°C; 53 h; Rate constant;
参考文献
Tanner, Dennis D.; Chen, Jian Jeffrey; Chen, Lucia; Luelo, Christine
Journal of the American Chemical Society, 1991 , vol. 113, # 21 p. 8074 - 8081
反应条件
potassium fluoride; ZnF2 in acetonitrile
T=100°C; 24 h;
参考文献
Borzeicka, Wioleta; Lavandera, Ivan; Gotor, Vicente
Journal of Organic Chemistry, 2013 , vol. 78, # 14 p. 7312 - 7317
反应条件
1: With 1,3-Dichloro-5,5-dimethyl-2,4-imidazolidinedione; trimethyl-(2-hydroxyethyl)ammonium chloride; toluene-4-sulfonic acid in acetonitrile
T=20°C; 1 h; Inert atmosphere;
2: With ZnF2; tetrabutyl ammonium fluoride in acetonitrile
T=80°C; 8 h; Inert atmosphere;
参考文献
Chen, Zizhan; Zhu, Wei; Zheng, Zubiao; Zou, Xinzhuo
Journal of Fluorine Chemistry, 2010 , vol. 131, # 3 p. 340 - 344
反应条件
hydroxymethanesulfinic acid sodium salt in ethanol
0.666667 h; Heating;
参考文献
Barkakaty, Balaka; Takaguchi, Yutaka; Tsuboi, Sadao
Tetrahedron, 2007 , vol. 63, # 4 p. 970 - 976
反应条件
1-(chloromethyl)-4-fluoro-1,4-diazoniabicyclo-[2.2.2]octane bis(tetrafluoroborate) in acetonitrile
T=20°C;
参考文献
Fuglseth, Erik; Thvedt, Thor Hakon Krane; Moll, Maria Forde; Hoff, Bard Helge
Tetrahedron, 2008 , vol. 64, # 30-31 p. 7318 - 7323
反应条件
1: With methanol; 1-(chloromethyl)-4-fluoro-1,4-diazoniabicyclo-[2.2.2]octane bis(tetrafluoroborate)
1.33333 h; Microwave irradiation;
2: With water
0.25 h; Microwave irradiation;
参考文献
Krane Thvedt, Thor Hakon; Fuglseth, Erik; Sundby, Eirik; Hoff, Bard Helge
Tetrahedron, 2009 , vol. 65, # 46 p. 9550 - 9556
反应条件
tetrabutylammonium hydrogen bifluoride in tetrahydrofuran
Heating;
参考文献
Fuglseth, Erik; Thvedt, Thor Hakon Krane; Moll, Maria Forde; Hoff, Bard Helge
Tetrahedron, 2008 , vol. 64, # 30-31 p. 7318 - 7323
反应条件
1: 58 percent / H5IO6; pyridinium chlorochromate / acetonitrile / 3.5 h / 20 °C
2: 58 percent / Rongalite / ethanol / 0.67 h / Heating
View Scheme
参考文献
Barkakaty, Balaka; Takaguchi, Yutaka; Tsuboi, Sadao
Tetrahedron, 2007 , vol. 63, # 4 p. 970 - 976
反应条件
pyridine hydrogenfluoride in diethyl ether
4 h; Ambient temperature; Yield given;
参考文献
Bridge, Colin F.; O'Hagan, David
Journal of Fluorine Chemistry, 1997 , vol. 82, # 1 p. 21 - 24
反应条件
1: diethyl ether
2: pyridinium poly(hydrogen fluoride) / diethyl ether / 4 h / Ambient temperature
View Scheme
参考文献
Bridge, Colin F.; O'Hagan, David
Journal of Fluorine Chemistry, 1997 , vol. 82, # 1 p. 21 - 24
