2-氟-4-硝基苯甲酸合成路线

参考文献

Jung, Michael E.; Ouk, Samedy; Yoo, Dongwon; Sawyers, Charles L.; Chen, Charlie; Tran, Chris; Wongvipat, John
Journal of Medicinal Chemistry, 2010 , vol. 53, # 7 p. 2779 - 2796

403-24-72-氟-4-硝基苯甲酸

34667-88-42-氟-4-硝基苯腈

参考文献

Bristol-Myers Squibb Pharma Company
Patent: US6369227 B1, 2002 ;
Location in patent: Page column 29 ;
US 6369227 B1

67-56-1甲醇+

403-24-72-氟-4-硝基苯甲酸

392-09-62-氟-4-硝基苯甲酸甲酯

参考文献

GRÜNENTHAL GMBH; FRANK, Robert; CHRISTOPH, Thomas; DAMANN, Nils; LESCH, Bernhard; BAHRENBERG, Gregor; SAUNDERS, Derek John; STOCKHAUSEN, Hannelore; KIM, Yong-Soo; KIM, Myeong-Seop; LEE, Jeewoo
Patent: WO2013/68467 A1, 2013 ;
Location in patent: Page/Page column 57; 59; 60; 61 ;

403-24-72-氟-4-硝基苯甲酸+

18107-18-1三甲基硅烷化重氮甲烷

392-09-62-氟-4-硝基苯甲酸甲酯

参考文献

CEPHALON, INC.; PHARMACOPEIA DRUG DISCOVERY, INC.
Patent: WO2008/51547 A1, 2008 ;
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WO 2008/051547 A1

186581-53-3重氮甲烷+

403-24-72-氟-4-硝基苯甲酸

392-09-62-氟-4-硝基苯甲酸甲酯

参考文献

ELI LILLY AND COMPANY
Patent: WO2004/14900 A1, 2004 ;
Location in patent: Page 52 ;
WO 2004/014900 A1

403-24-72-氟-4-硝基苯甲酸

392-09-62-氟-4-硝基苯甲酸甲酯

参考文献

Goldstein; Urvater
Helvetica Chimica Acta, 1951 , vol. 34, p. 1350,1354

403-24-72-氟-4-硝基苯甲酸

446-31-14-氨基-2-氟苯甲酸

参考文献

STEIN, Philip; DAINES, Robert; SPROUS, Dennis; O'GRADY, Harold
Patent: WO2010/132615 A1, 2010 ;
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WO 2010/132615 A1

403-24-72-氟-4-硝基苯甲酸

210416-38-9

参考文献

Gangjee, Aleem; Jain, Hiteshkumar D.; McGuire, John J.; Kisliuk, Roy L.
Journal of Medicinal Chemistry, 2004 , vol. 47, # 27 p. 6730 - 6739

403-24-72-氟-4-硝基苯甲酸

660432-43-9

参考文献

GRÜNENTHAL GMBH; FRANK, Robert; CHRISTOPH, Thomas; DAMANN, Nils; LESCH, Bernhard; BAHRENBERG, Gregor; SAUNDERS, Derek John; STOCKHAUSEN, Hannelore; KIM, Yong-Soo; KIM, Myeong-Seop; LEE, Jeewoo
Patent: WO2013/68467 A1, 2013 ;

403-24-72-氟-4-硝基苯甲酸

73792-06-04-氨基-2-氟苯甲酸乙酯

参考文献

Radeke, Heike S.; Purohit, Ajay; Harris, Thomas D.; Hanson, Kelley; Jones, Reinaldo; Hu, Carol; Yalamanchili, Padmaja; Hayes, Megan; Yu, Ming; Guaraldi, Mary; Kagan, Mikhail; Azure, Michael; Cdebaca, Michael; Robinson, Simon; Casebier, David
ACS Medicinal Chemistry Letters, 2011 , vol. 2, # 9 p. 650 - 655