3-氟-4-甲氧基苯甲酸合成路线

331-62-43-氟-4-甲氧基苯腈→403-20-33-氟-4-甲氧基苯甲酸

参考文献

CENTAURUS BIOPHARMA CO., LTD.; XIAO, Dengming; ZHU, Li; HU, Yuandong; YU, Rong; HU, Wei; ZHAO, Na; PENG, Yong; LUO, Hong; HAN, Yongxin
Patent: WO2013/97773 A1, 2013 ;
Location in patent: Paragraph 0172 ;

369-30-23-氟-4-甲氧基苯甲酸甲酯→403-20-33-氟-4-甲氧基苯甲酸

参考文献

EXELIXIS, INC.
Patent: WO2009/55077 A1, 2009 ;
Location in patent: Page/Page column 371 ;

124-38-9二氧化碳+2357-52-04-溴-2-氟苯甲醚→403-20-33-氟-4-甲氧基苯甲酸

参考文献

Ziobro, Dorota; Dziaduszek, Jerzy; Filipowicz, Marek; Dabrowski, Roman; Czu, Joanna; Urban, Stanislaw
Molecular Crystals and Liquid Crystals, 2009 , vol. 502, p. 258 - 271

399-55-32-氟-4-甲基苯甲醚→403-20-33-氟-4-甲氧基苯甲酸

参考文献

Hansen
Journal of the American Chemical Society, 1937 , vol. 59, p. 280

74-83-9溴甲烷+350-29-83-氟-4-羟基苯甲酸→403-20-33-氟-4-甲氧基苯甲酸

参考文献

Gray, G. W.; Hogg, C.; Lacey, D.
Molecular Crystals and Liquid Crystals (1969-1991), 1981 , vol. 67, p. 1 - 24

109-72-8正丁基锂+2357-52-04-溴-2-氟苯甲醚→403-20-33-氟-4-甲氧基苯甲酸

参考文献

Morgan et al.
Journal of the American Chemical Society, 1955 , vol. 77, p. 5658

2357-52-04-溴-2-氟苯甲醚→403-20-33-氟-4-甲氧基苯甲酸

参考文献

CENTAURUS BIOPHARMA CO., LTD.; XIAO, Dengming; ZHU, Li; HU, Yuandong; YU, Rong; HU, Wei; ZHAO, Na; PENG, Yong; LUO, Hong; HAN, Yongxin
Patent: WO2013/97773 A1, 2013 ;

2105-94-44-溴-2-氟苯酚→403-20-33-氟-4-甲氧基苯甲酸

参考文献

Gray, G. W.; Hogg, C.; Lacey, D.
Molecular Crystals and Liquid Crystals (1969-1991), 1981 , vol. 67, p. 1 - 24

367-12-42-氟苯酚→403-20-33-氟-4-甲氧基苯甲酸

参考文献

Yerande, Swapnil G.; Shendage, Deepak M.; Wakchaure, Prasad B.; Phadtare, Ganesh R.; Bhoite, Madhavrao Y.; Gangopadhyay, Ashok Kumar; Nagarajan, Kuppuswamy; Rupp, Richard Helmut
Tetrahedron Letters, 2014 , vol. 55, # 15 p. 2426 - 2429

405-04-93-氟-4-羟基苯腈→403-20-33-氟-4-甲氧基苯甲酸

参考文献

Gray, G. W.; Hogg, C.; Lacey, D.
Molecular Crystals and Liquid Crystals (1969-1991), 1981 , vol. 67, p. 1 - 24