ARG-PRO-LYS-PRO-GLN-GLN-PHE-PHE-GLY-LEU-MET: RPKPQQFFGLM合成路线 （共 14 条）
反应条件
hydrogenchloride in acetic acid
1 h;
参考文献
Allen; Brundish; Wade; Sandberg; Hanley; Iversen
Journal of Medicinal Chemistry, 1982 , vol. 25, # 10 p. 1209 - 1213
反应条件
ammonia in methanol
48 h; Ambient temperature;
参考文献
Lipkowski, Andrzej W.; Majewski, Tadeusz; Drabarek, Stefania
Polish Journal of Chemistry, 1980 , vol. 54, # 2 p. 373 - 374
反应条件
2: 100 percent / HCl / acetic acid / 1 h
View Scheme
参考文献
Allen; Brundish; Wade; Sandberg; Hanley; Iversen
Journal of Medicinal Chemistry, 1982 , vol. 25, # 10 p. 1209 - 1213
反应条件
1: 63 percent / thermolysin / ethyl acetate; various solvent(s) / 20 h / 37 °C
2: HBr, glacial AcOH
4: HCl, AcOH
View Scheme
参考文献
Kuhl, Peter; Doering, Guenter; Neubert, Klaus; Jakubke, Hans-Dieter
Monatshefte fuer Chemie, 1984 , vol. 115, p. 423 - 430
反应条件
1: 72 percent / α-chymotrypsin / CCl4; various solvent(s) / 2 h / Ambient temperature
2: HBr, glacial AcOH
4: HCl, AcOH
View Scheme
参考文献
Kuhl, Peter; Doering, Guenter; Neubert, Klaus; Jakubke, Hans-Dieter
Monatshefte fuer Chemie, 1984 , vol. 115, p. 423 - 430
反应条件
1: 77.7 percent / HCl, thioanisole / ethyl acetate / 0.5 h / Ambient temperature
2: 1.) N-methylmorpholine, isobutyl chloroformate / 1.) DMF, -20 deg C, 5 min, 2.) 2 h
3: 92 percent / NH3 / methanol / 48 h / Ambient temperature
4: 93 percent / HCl, thioanisole / ethyl acetate / 0.5 h / Ambient temperature
View Scheme
参考文献
Chorev; Yaion; Wormser; et al.
European Journal of Medicinal Chemistry, 1986 , vol. 21, # 2 p. 96 - 102
反应条件
1: 92 percent / NH3 / methanol / 48 h / Ambient temperature
2: 93 percent / HCl, thioanisole / ethyl acetate / 0.5 h / Ambient temperature
View Scheme
参考文献
Chorev; Yaion; Wormser; et al.
European Journal of Medicinal Chemistry, 1986 , vol. 21, # 2 p. 96 - 102
反应条件
1: 1.) N-methylmorpholine, isobutyl chloroformate / 1.) DMF, -20 deg C, 5 min, 2.) 2 h
2: 92 percent / NH3 / methanol / 48 h / Ambient temperature
3: 93 percent / HCl, thioanisole / ethyl acetate / 0.5 h / Ambient temperature
View Scheme
参考文献
Chorev; Yaion; Wormser; et al.
European Journal of Medicinal Chemistry, 1986 , vol. 21, # 2 p. 96 - 102
反应条件
1: HBr, glacial AcOH
3: HCl, AcOH
View Scheme
参考文献
Kuhl, Peter; Doering, Guenter; Neubert, Klaus; Jakubke, Hans-Dieter
Monatshefte fuer Chemie, 1984 , vol. 115, p. 423 - 430
反应条件
2: HCl, AcOH
View Scheme
参考文献
Kuhl, Peter; Doering, Guenter; Neubert, Klaus; Jakubke, Hans-Dieter
Monatshefte fuer Chemie, 1984 , vol. 115, p. 423 - 430
