1.1: bis(trichloromethyl) carbonate; 4-methyl-morpholine / dichloromethane / 3.08 h / -78 - -30 °C 2.1: dichloromethane / 72 h / 20 °C 3.1: potassium carbonate; methanol / 0.5 h / 20 °C 3.2: 20 °C View Scheme

1: diisopropyl-carbodiimide; 4-methyl-morpholine; copper dichloride / N,N-dimethyl-formamide / 5 h / 20 °C 2: sodium hydroxide; water / tetrahydrofuran / 18 h / 20 °C 3: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / dichloromethane / 6 h / 20 °C / |Cooling with ice 4: sodium hydrogencarbonate; potassium bromide; 2,2,6,6-tetramethyl-1-piperidinyloxy, free radical; sodium hypochlorite / dichloromethane / 20 h / 20 °C / |Cooling with ice View Scheme

1: sodium hydroxide; water / tetrahydrofuran / 18 h / 20 °C 2: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / dichloromethane / 6 h / 20 °C / |Cooling with ice 3: sodium hydrogencarbonate; potassium bromide; 2,2,6,6-tetramethyl-1-piperidinyloxy, free radical; sodium hypochlorite / dichloromethane / 20 h / 20 °C / |Cooling with ice View Scheme

1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / dichloromethane / 6 h / 20 °C / |Cooling with ice 2: sodium hydrogencarbonate; potassium bromide; 2,2,6,6-tetramethyl-1-piperidinyloxy, free radical; sodium hypochlorite / dichloromethane / 20 h / 20 °C / |Cooling with ice View Scheme

1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / N,N-dimethyl-formamide 2: water; trifluoroacetic acid / acetone / 22 h View Scheme