2-[5-(4-甲基哌嗪)苯并咪唑-2-基]乙酸乙酯合成路线 （共 6 条）
反应条件
potassium tert-butylate in tetrahydrofuran; toluene T=17 - 30°C; 2 h;
参考文献
NOVARTIS AG
Patent: WO2006/125130 A1, 2006 ;
Location in patent: Page/Page column 70-71 ;
反应条件
1: in ethanol; water
T=45 - 55°C; 2.5 h;
2: With sodium hydroxide in water
T=25 - 30°C; pH=9 - 10; 4.33 h;
参考文献
Novartis AG
Patent: US2008/293738 A1, 2008 ;
Location in patent: Page/Page column 11; 13-14 ;
反应条件
H2; sodium hydroxide; palladium monocarbide in hydrogenchloride
参考文献
CHIRON CORPORATION
Patent: US2005/256157 A1, 2005 ;
US 20050256157 A1
反应条件
1: 99 percent / ethanol / 40 h / 97 °C
2: H2 / Pd/C / aq. ethanol / 6 h / 40 - 50 °C
3: 1.98 kg / aq. ethanol / 2 h
View Scheme
参考文献
Zhu, Shuguang; Harwood, Eric; Cai, Shaopei; Shang, Xiao; Galvin, Gabriel; Jin, Li; Yeung, Arthur; Diaz, Brian; Zheng, Minna; Ryckman, David
Chimia, 2006 , vol. 60, # 9 p. 584 - 592
反应条件
1: 99 percent / ethanol / 40 h / 97 °C
2: H2 / Pd/C / aq. ethanol / 6 h / 40 - 50 °C
3: 1.98 kg / aq. ethanol / 2 h
View Scheme
参考文献
Zhu, Shuguang; Harwood, Eric; Cai, Shaopei; Shang, Xiao; Galvin, Gabriel; Jin, Li; Yeung, Arthur; Diaz, Brian; Zheng, Minna; Ryckman, David
Chimia, 2006 , vol. 60, # 9 p. 584 - 592
反应条件
1: H2 / Pd/C / aq. ethanol / 6 h / 40 - 50 °C
2: 1.98 kg / aq. ethanol / 2 h
View Scheme
参考文献
Zhu, Shuguang; Harwood, Eric; Cai, Shaopei; Shang, Xiao; Galvin, Gabriel; Jin, Li; Yeung, Arthur; Diaz, Brian; Zheng, Minna; Ryckman, David
Chimia, 2006 , vol. 60, # 9 p. 584 - 592
