3-甲基吡唑-5-甲酸乙酯合成路线 （共 40 条）
反应条件
1: ethyl 3-methyl-5-pyrazolecarboxylate With sodium hydride in tetrahydrofuran T=0 - 20°C; Inert atmosphere; 2: methyl iodide in tetrahydrofuran T=20°C; 12 h; Inert atmosphere; regioselective reaction;
参考文献
Seubert, Christoph K.; Sun, Yu; Lan, Yanhua; Powell, Annie K.; Thiel, Werner R.
European Journal of Inorganic Chemistry, 2011 , # 11 p. 1768 - 1775
反应条件
1: ethyl 3-methyl-5-pyrazolecarboxylate With sodium hydride in tetrahydrofuran 2 h; 2: methyl iodide With sodium hydroxide in tetrahydrofuran 2 h;
参考文献
v. Auwers; Breyhan
Journal fuer Praktische Chemie (Leipzig), 1935 , vol. <2> 143, p. 259,273
Full Text Show Details
Papesch; Dodson
Journal of Organic Chemistry, 1965 , vol. 30, p. 199,202
参考文献
v. Auwers; Breyhan
Journal fuer Praktische Chemie (Leipzig), 1935 , vol. <2> 143, p. 259,273
参考文献
Terrett, Nicholas K.; Bell, Andrew S.; Brown, David; Ellis, Peter
Bioorganic and Medicinal Chemistry Letters, 1996 , vol. 6, # 15 p. 1819 - 1824
参考文献
Nissan Chemical Industries, Ltd.
Patent: US5817829 A1, 1998 ;
反应条件
2: NaOH / H2O View Scheme
参考文献
Terrett, Nicholas K.; Bell, Andrew S.; Brown, David; Ellis, Peter
Bioorganic and Medicinal Chemistry Letters, 1996 , vol. 6, # 15 p. 1819 - 1824
反应条件
sodium hydroxide; ethanol 1 h; Heating / reflux;
参考文献
BIOLIPOX AB
Patent: WO2006/32851 A1, 2006 ;
Location in patent: Page/Page column 39-40 ;
参考文献
Dewar; King
Journal of the Chemical Society, 1945 , p. 114
Full Text Show Details
Musante; Mugnaini
Gazzetta Chimica Italiana, 1947 , vol. 77, p. 182,193
反应条件
lithium aluminium tetrahydride; diethyl ether
参考文献
Chen, Chao; Qiu, Huayu; Chen, Wanzhi
Inorganic Chemistry, 2011 , vol. 50, # 17 p. 8671 - 8678
反应条件
1: diethyl ether; SO2Cl2 View Scheme
参考文献
v.Auwers; Cauer
Journal fuer Praktische Chemie (Leipzig), 1930 , vol. <2>126, p. 150,165
Chemische Berichte, 1928 , vol. 61, p. 2405
