5-苯基-3-三氟甲基吡唑合成路线 （共 23 条）
反应条件
1: in 1,2-dichloro-benzene T=180°C; 24 h; Sealed tube; 2: With palladium hydroxide on carbon; hydrogen; acetic acid in methanol T=80°C; P=52505.3 Torr; 7 h; Flow reactor;
参考文献
Foster, Robert S.; Adams, Harry; Jakobi, Harald; Harrity, Joseph P. A.
Journal of Organic Chemistry, 2013 , vol. 78, # 8 p. 4049 - 4064
反应条件
triethylamine in tetrahydrofuran 1200 h; Ambient temperature;
参考文献
Jin, Fuqiang; Xu, Yuanyao; Ma, Yiling
Tetrahedron Letters, 1992 , vol. 33, # 41 p. 6161 - 6164
反应条件
1: 91 percent / Et3N / Pd(PPh3)2Cl2, CuI / acetonitrile / 1 h / Heating 2: 99 percent / H2NNH2*H2O / ethanol / 2 h / 60 °C View Scheme
参考文献
Li, Feng; Nie, Jing; Sun, Long; Zheng, Yan; Ma, Jun-An
Angewandte Chemie - International Edition, 2013 , vol. 52, # 24 p. 6255 - 6258
反应条件
sodium acetate; silver(l) oxide in N,N-dimethyl-formamide T=45°C; 5 h; Schlenk technique; regioselective reaction;
参考文献
Li, Feng; Nie, Jing; Sun, Long; Zheng, Yan; Ma, Jun-An
Angewandte Chemie - International Edition, 2013 , vol. 52, # 24 p. 6255 - 6258
反应条件
1: 72 percent / NaH / tetrahydrofuran / Ambient temperature; 1.) 20 min, 2.) 15 min 2: 90 percent / H2NNH2*H2O / ethanol / 2 h / 60 °C View Scheme
参考文献
Yu, Hong-Bin; Huang, Wei-Yuan
Journal of Fluorine Chemistry, 1997 , vol. 84, # 1 p. 65 - 67
反应条件
1: conc. aq. HCl / methanol 2: KOH / methanol / 0.08 h / Heating View Scheme
参考文献
Shi, Guoqiang; Xu, Yuanyao
Journal of Fluorine Chemistry, 1990 , vol. 46, # 1 p. 173 - 178
反应条件
1: KOH / methanol / 0.08 h / Heating View Scheme
参考文献
Shi, Guoqiang; Xu, Yuanyao
Journal of Fluorine Chemistry, 1990 , vol. 46, # 1 p. 173 - 178
反应条件
1: With hydrazine in 1,4-dioxane 2: in toluene Heating; Further stages.;
参考文献
Jeon, Sung Lan; Choi, Ji Hoon; Kim, Bum Tae; Jeong, In Howa
Journal of Fluorine Chemistry, 2007 , vol. 128, # 10 p. 1191 - 1197
反应条件
1: caesium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II) dichloromethane adduct / water; propan-1-ol / 1 h / 110 °C / |Inert atmosphere; |Sealed tube; |Microwave irradiation 2: sulfuric acid / 5 h / 130 °C View Scheme
参考文献
Ermolenko, Mikhail S.; Guillou, Sandrine; Janin, Yves L.
Tetrahedron, 2013 , vol. 69, # 1 p. 257 - 263
反应条件
in ethanol 6 h; Reflux;
参考文献
Aggarwal, Ranjana; Kumar, Rajiv; Singh, Shiv P.
Journal of Fluorine Chemistry, 2009 , vol. 130, # 10 p. 886 - 893
