6-脱氧-6-碘-1,2:3,4-二-o-异亚丙基-α-d-半乳糖吡喃糖苷合成路线 (共 31 条)
反应条件
tetra-(n-butyl)ammonium iodide in benzene
2 h; Heating;
参考文献
Binkley; Ambrose; Hehemann
Journal of Organic Chemistry, 1980 , vol. 45, # 22 p. 4387 - 4391
反应条件
lithium iodide in N,N,N',N',N'',N''-hexamethylphosphoric triamide; toluene
3.5 h; Heating;
参考文献
Paulsen, Hans; Stubbe, Mathias; Heiker, Fred R.
Liebigs Annalen der Chemie, 1980 , # 6 p. 825 - 837
反应条件
1: 92 percent / H2SO4 / 24 h
2: 80 percent / I2; PPh3; imidazol / toluene / 24 h / Heating
View Scheme
参考文献
Braga, Fernanda Gambogi; Coimbra, Elaine Soares; de Oliveira Matos, Magnum; Lino Carmo, Arturene Maria; Cancio, Marisa Damato; da Silva, Adilson David
European Journal of Medicinal Chemistry, 2007 , vol. 42, # 4 p. 530 - 537
反应条件
acetone; sodium iodide
参考文献
Foster et al.
Journal of the Chemical Society, 1949 , p. 2542,2545
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Raymond; Schroeder
Journal of the American Chemical Society, 1948 , vol. 70, p. 2785,2790
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Freudenberg; Raschig
Chemische Berichte, 1927 , vol. 60, p. 1633
Chemische Berichte, 1929 , vol. 62, p. 373
参考文献
Vatele, Jean-Michel; Hanessian, Stephen
Tetrahedron, 1996 , vol. 52, # 32 p. 10557 - 10568
反应条件
copper(l) iodide; 2-propenylmagnesium bromide in diethyl ether
48 h; Ambient temperature; Title compound not separated from byproducts;
参考文献
Mootoo, David; Wilson, Phyllis; Jammalamadaka, Vasu
Journal of Carbohydrate Chemistry, 1994 , vol. 13, # 6 p. 841 - 850
反应条件
1: H2SO4
2: 82 percent / PPh3, imidazole, I2 / toluene / 0.25 h / Heating
View Scheme
参考文献
Mereyala, Hari Babu; Gaddam, Reddy
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1994 , # 15 p. 2187 - 2190
反应条件
1: zinc(II) chloride
2: 1H-imidazole; iodine; triphenylphosphine / tetrahydrofuran / 1 h / Reflux
View Scheme
参考文献
Timmer, Mattie S.M.; Dangerfield, Emma M.; Cheng, Janice M.H.; Gulab, Shivali A.; Stocker, Bridget L.
Tetrahedron Letters, 2011 , vol. 52, # 37 p. 4803 - 4805
反应条件
copper(l) iodide in diethyl ether
48 h; Ambient temperature; Title compound not separated from byproducts;
参考文献
Mootoo, David; Wilson, Phyllis; Jammalamadaka, Vasu
Journal of Carbohydrate Chemistry, 1994 , vol. 13, # 6 p. 841 - 850
参考文献
Overend; Vaughan
Journal of the Chemical Society, 1954 , p. 2155