3,5-二甲基-1H-吡咯-2-甲酸苄酯合成路线 （共 13 条）
反应条件
1: 1.) POCl3 / 1.) CH2Cl2, <10 deg C, 2.) room temp., 2 h 2: 95 percent / piperidine, AcOH / toluene / 3.5 h / Heating 3: H2, Et3N / 10percent Pd/C / Ambient temperature 4: 1.) CF3COOH / 1.) 10 min, 2.) 0 deg C, 10 min View Scheme
参考文献
Smith, Kevin M.; Pandey, Ravindra K.; Tabba, Hani D.
Journal of Chemical Research, Miniprint, 1986 , # 11 p. 3333 - 3357
反应条件
hydrogen; palladium on activated charcoal
参考文献
Yon-Hin, Paul; Ian Scott
Tetrahedron Letters, 1991 , vol. 32, # 34 p. 4231 - 4234
反应条件
1: 71 percent / lead tetraacetate / CHCl3 2: 82 percent / H2, triethylamine / 10percent Pd/C / tetrahydrofuran / 0.5 h / Ambient temperature 3: 31 percent / 2-amino-ethanol / 0.33 h / 200 °C View Scheme
参考文献
Montforts, Franz-Peter; Schwartz, Ulrich Manfred
Liebigs Annalen der Chemie, 1991 , # 8 p. 709 - 726
反应条件
1: 71 percent / lead tetraacetate / CHCl3 2: 82 percent / H2, triethylamine / 10percent Pd/C / tetrahydrofuran / 0.5 h / Ambient temperature View Scheme
参考文献
Montforts, Franz-Peter; Schwartz, Ulrich Manfred
Liebigs Annalen der Chemie, 1991 , # 8 p. 709 - 726
反应条件
hydrogen; Raney nickel (W-2) in tetrahydrofuran
P=1551.4 Torr; 1.5 h;
参考文献
Smith, Kevin M.; Minnetian, Ohannes M.
Journal of Organic Chemistry, 1985 , vol. 50, # 12 p. 2073 - 2080
反应条件
toluene-4-sulfonic acid; ethylene glycol
0.133333 h; microwave irradiation;
参考文献
Regourd, Jasmine; Comeau, Ian M.; Beshara, Cory S.; Thompson, Alison
Journal of Heterocyclic Chemistry, 2006 , vol. 43, # 6 p. 1709 - 1714
反应条件
in benzyl alcohol
T=209°C; 0.5 h;
参考文献
Robinson, John A.; McDonald, Edward; Battersby, Alan R.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1985 , p. 1699 - 1710
参考文献
Montforts, Franz-Peter; Schwartz, Ulrich Manfred
Liebigs Annalen der Chemie, 1991 , # 8 p. 709 - 726
反应条件
1: 63.5 percent / sodium nitrite, Zn / acetic acid / 90 min below 5 deg C, 4 h room temp., 1 h 75 deg C, 1 h 85 deg C
2: 95 percent / phenylmethanol / 0.5 h / 209 °C
View Scheme
参考文献
Robinson, John A.; McDonald, Edward; Battersby, Alan R.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1985 , p. 1699 - 1710
反应条件
benzylation; Yield given;
参考文献
Nishide, Hiroyuki; Hashimoto, Yukio; Maeda, Hiromi; Tsuchida, Eishun
Journal of the Chemical Society, Dalton Transactions: Inorganic Chemistry (1972-1999), 1987 , p. 2963 - 2968
