1H-吡唑-1-甲脒盐酸盐合成路线

→288-13-1吡唑

参考文献

3-Dimensional Pharmaceuticals, Inc.
Patent: US6235778 B1, 2001 ;
US 6235778 B1

108-91-8环己胺+4023-02-31H-吡唑-1-甲脒盐酸盐→2498-47-7N-环己基胍盐酸盐

参考文献

Bernatowicz, Michael S.; Wu, Youling; Matsueda, Gary R.
Journal of Organic Chemistry, 1992 , vol. 57, # 8 p. 2497 - 2502

4023-02-31H-吡唑-1-甲脒盐酸盐→289-95-2嘧啶

参考文献

Chiron Corporation
Patent: US6417185 B1, 2002 ;
US 6417185 B1

4023-02-31H-吡唑-1-甲脒盐酸盐+60-32-26-氨基己酸→6659-35-46-胍基己酸盐酸盐

参考文献

Nowak, Pawel; Cole, Derek C.; Aulabaugh, Ann; Bard, Jonathan; Chopra, Rajiv; Cowling, Rebecca; Fan, Kristi Y.; Hu, Baihua; Jacobsen, Steve; Jani, Minakshi; Jin, Guixan; Lo, Mei-Chu; Malamas, Michael S.; Manas, Eric S.; Narasimhan, Rani; Reinhart, Peter; Robichaud, Albert J.; Stock, Joseph R.; Subrath, Joan; Svenson, Kristine; Turner, Jim; Wagner, Erik; Zhou, Ping; Ellingboe, John W.
Bioorganic and Medicinal Chemistry Letters, 2010 , vol. 20, # 2 p. 632 - 635

4023-02-31H-吡唑-1-甲脒盐酸盐+103-67-3N-甲基苄胺→330-69-81-苄基-1-甲基胍盐酸盐

参考文献

BRISTOL-MYERS SQUIBB COMPANY
Patent: WO2004/106296 A2, 2004 ;
Location in patent: Page 34 ;

501-53-1氯甲酸苄酯+4023-02-31H-吡唑-1-甲脒盐酸盐→152120-62-2N-Cbz-1H-吡咯-1-甲眯

参考文献

Bernatowicz, Michael S.; Wu, Youling; Matsueda, Gary R.
Tetrahedron Letters, 1993 , vol. 34, # 21 p. 3389 - 3392

4023-02-31H-吡唑-1-甲脒盐酸盐+139110-70-6扎那米韦→139110-80-8扎那米韦

参考文献

Zhu, Xue-Bin; Wang, Meng; Wang, Shaozhong; Yao, Zhu-Jun
Tetrahedron, 2012 , vol. 68, # 8 p. 2041 - 2044

24424-99-5二碳酸二叔丁酯+4023-02-31H-吡唑-1-甲脒盐酸盐+152120-61-1N-Boc-1H-吡唑-1-甲脒→152120-54-2N,N'-二-Boc-1H-1-胍基吡唑

参考文献

WO2008/126943 A2, ;

Page/Page column 78-79 ;

24424-99-5二碳酸二叔丁酯+4023-02-31H-吡唑-1-甲脒盐酸盐→152120-54-2N,N'-二-Boc-1H-1-胍基吡唑

参考文献

Synthesis, , # 6 p. 579 - 582

475483-21-7(4S,5R,6R)-5-乙酰氨基-4-氨基-6-((1R,2R)-2,3-二羟基-1-甲氧基丙基)-5,6-二氢-4H-吡喃-2-羧酸+4023-02-31H-吡唑-1-甲脒盐酸盐→203120-17-6(4S,5R,6R)-5-乙酰氨基-4-胍基-6-((1R,2R)-2,3-二羟基-1-甲氧基丙基)-5,6-二氢-4H-吡喃-2-甲酸

参考文献

WO2008/126943 A2, ;

Page/Page column 77-78 ;