4-(4-甲氧基苯基)-3-硫代氨基甲酰肼合成路线 （共 15 条）
反应条件
hydrazine in ethanol T=0 - 20°C; 4 h;
参考文献
NIPPON KAYAKU KABUSHIKI KAISHA
Patent: EP1857446 A1, 2007 ;
Location in patent: Page/Page column 27 ;
反应条件
1: With sodium hydroxide in N,N-dimethyl-formamide T=20 - 35°C; 1 h; 2: With hydrazine hydrate in N,N-dimethyl-formamide T=60 - 70°C; 1 h;
参考文献
Tripathi, Laxmi; Kumar, Praveen
European Journal of Medicinal Chemistry, 2013 , vol. 64, p. 477 - 487
反应条件
carbon disulfide; sodium carbonate; chloroacetic acid; hydrazine in ethanol; water
参考文献
Schering Corporation
Patent: US5506236 A1, 1996 ;
参考文献
Schering Corporation
Patent: US5506236 A1, 1996 ;
反应条件
1: sodium hydrogencarbonate / chloroform; water / 1 h / 20 °C 2: hydrazine / dichloromethane; water / 1 h View Scheme
参考文献
Radl, Stanislav; Zikan, Viktor
Collection of Czechoslovak Chemical Communications, 1986 , vol. 51, # 8 p. 1692 - 1697
反应条件
sodium salt of the chloroacetic acid; hydrazine hydrate in ethanol; water T=60°C; 4 h;
参考文献
Shi, Zhi Chuan; Zhao, Zhi Gang; Liu, Xing Li; Chen, Yu
Chinese Chemical Letters, 2011 , vol. 22, # 4 p. 405 - 408
反应条件
hydrazine hydrate in ethanol T=80°C; 1 h;
参考文献
Sriram, Dharmarajan; Yogeeswari, Perumal; Dhakla, Prathiba; Senthilkumar, Palaniappan; Banerjee, Debjani; Manjashetty, Thimmappa H.
Bioorganic and Medicinal Chemistry Letters, 2009 , vol. 19, # 4 p. 1152 - 1154
反应条件
1: in ethanol 2: With hydrazine hydrate in ethanol T=60°C; 4 h;
参考文献
Zhao, Zhigang; Liu, Xingli; Liu, Lingling; Li, Guohua
Journal of Chemical Research, 2010 , # 8 p. 455 - 458
反应条件
hydrazine hydrate in ethanol 16 h; Reflux;
参考文献
Siddiqui, Nadeem; Ahsan, Waquar
Medicinal Chemistry Research, 2011 , vol. 20, # 2 p. 261 - 268
反应条件
1: ethanol / 0.5 h / 20 °C 2: hydrazine hydrate / ethanol / 1 h / 20 °C View Scheme
参考文献
Liu, Yang; Lu, Wei-Qiang; Cui, Kun-Qiang; Luo, Wei; Wang, Jian; Guo, Chun
Archives of Pharmacal Research, 2012 , vol. 35, # 9 p. 1525 - 1531
